1WND
Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009310 | biological_process | amine catabolic process |
| A | 0009447 | biological_process | putrescine catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| A | 0019477 | biological_process | L-lysine catabolic process |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0051289 | biological_process | protein homotetramerization |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009310 | biological_process | amine catabolic process |
| B | 0009447 | biological_process | putrescine catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| B | 0019477 | biological_process | L-lysine catabolic process |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0051289 | biological_process | protein homotetramerization |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009310 | biological_process | amine catabolic process |
| C | 0009447 | biological_process | putrescine catabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| C | 0019477 | biological_process | L-lysine catabolic process |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051287 | molecular_function | NAD binding |
| C | 0051289 | biological_process | protein homotetramerization |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009310 | biological_process | amine catabolic process |
| D | 0009447 | biological_process | putrescine catabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| D | 0019477 | biological_process | L-lysine catabolic process |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051287 | molecular_function | NAD binding |
| D | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 475 |
| Chain | Residue |
| A | GLY249 |
| A | LYS250 |
| A | ALA251 |
| A | LEU406 |
| A | ALA407 |
| A | TYR427 |
| A | HOH497 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 475 |
| Chain | Residue |
| D | ALA251 |
| D | LEU406 |
| D | ALA407 |
| D | TYR427 |
| D | GLY249 |
| D | LYS250 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 475 |
| Chain | Residue |
| B | GLY249 |
| B | LYS250 |
| B | LEU406 |
| B | ALA407 |
| B | TYR427 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 475 |
| Chain | Residue |
| C | GLY249 |
| C | LYS250 |
| C | ALA251 |
| C | LEU406 |
| C | ALA407 |
| C | TYR427 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. MELGGKAP |
| Chain | Residue | Details |
| A | MET245-PRO252 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15381418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WNB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS280 | |
| A | ASN149 | |
| A | GLU246 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS280 | |
| B | ASN149 | |
| B | GLU246 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | CYS280 | |
| C | ASN149 | |
| C | GLU246 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | CYS280 | |
| D | ASN149 | |
| D | GLU246 |
