Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1WND

Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase as determined by kinetics and crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0005829	cellular_component	cytosol
A	0009447	biological_process	putrescine catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
A	0019477	biological_process	L-lysine catabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0051287	molecular_function	NAD binding
A	0051289	biological_process	protein homotetramerization
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0005829	cellular_component	cytosol
B	0009447	biological_process	putrescine catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
B	0019477	biological_process	L-lysine catabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0051287	molecular_function	NAD binding
B	0051289	biological_process	protein homotetramerization
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0005829	cellular_component	cytosol
C	0009447	biological_process	putrescine catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
C	0019477	biological_process	L-lysine catabolic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0051287	molecular_function	NAD binding
C	0051289	biological_process	protein homotetramerization
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0005829	cellular_component	cytosol
D	0009447	biological_process	putrescine catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
D	0019477	biological_process	L-lysine catabolic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0051287	molecular_function	NAD binding
D	0051289	biological_process	protein homotetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 475

Chain	Residue
A	GLY249
A	LYS250
A	ALA251
A	LEU406
A	ALA407
A	TYR427
A	HOH497

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 475

Chain	Residue
D	ALA251
D	LEU406
D	ALA407
D	TYR427
D	GLY249
D	LYS250

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 475

Chain	Residue
B	GLY249
B	LYS250
B	LEU406
B	ALA407
B	TYR427

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 475

Chain	Residue
C	GLY249
C	LYS250
C	ALA251
C	LEU406
C	ALA407
C	TYR427

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. MELGGKAP

Chain	Residue	Details
A	MET245-PRO252

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255\|PROSITE-ProRule:PRU10007

Chain	Residue	Details
A	GLU246
B	GLU246
C	GLU246
D	GLU246

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000305

Chain	Residue	Details
A	CYS280
B	CYS280
C	CYS280
D	CYS280

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:15381418, ECO:0007744\|PDB:1WNB

Chain	Residue	Details
A	ALA146
B	CYS280
C	ALA146
C	LYS172
C	ASP209
C	SER225
C	CYS280
D	ALA146
D	LYS172
D	ASP209
D	SER225
A	LYS172
D	CYS280
A	ASP209
A	SER225
A	CYS280
B	ALA146
B	LYS172
B	ASP209
B	SER225

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS280
A	ASN149
A	GLU246

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS280
B	ASN149
B	GLU246

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS280
C	ASN149
C	GLU246

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS280
D	ASN149
D	GLU246

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)