1WM9

Structure of GTP cyclohydrolase I from Thermus thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS108
A	HIS111
A	CYS179

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1002

Chain	Residue
B	CYS108
B	HIS111
B	CYS179

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1003

Chain	Residue
C	HOH1018
C	CYS108
C	HIS111
C	CYS179

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 1004

Chain	Residue
D	CYS108
D	HIS111
D	CYS179

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 1005

Chain	Residue
E	CYS108
E	HIS111
E	CYS179

---

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVvvKGVefySmCEHH

Chain	Residue	Details
A	GLU95-HIS111

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
A	HIS177
A	HIS110

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
B	HIS177
B	HIS110

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
C	HIS177
C	HIS110

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
D	HIS177
D	HIS110

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
E	HIS177
E	HIS110

---