1WLE
Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004828 | molecular_function | serine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006434 | biological_process | seryl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0070158 | biological_process | mitochondrial seryl-tRNA aminoacylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004828 | molecular_function | serine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006434 | biological_process | seryl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0070158 | biological_process | mitochondrial seryl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SRP A 900 |
| Chain | Residue |
| A | THR282 |
| A | GLU401 |
| A | VAL402 |
| A | THR403 |
| A | SER404 |
| A | ASN434 |
| A | THR436 |
| A | ALA439 |
| A | HOH902 |
| A | HOH954 |
| A | HOH1040 |
| A | GLU284 |
| A | HOH1134 |
| A | ARG313 |
| A | GLU315 |
| A | TYR326 |
| A | ARG327 |
| A | VAL328 |
| A | PHE331 |
| A | GLU335 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SRP B 901 |
| Chain | Residue |
| B | THR282 |
| B | GLU284 |
| B | ARG313 |
| B | GLU315 |
| B | TYR326 |
| B | ARG327 |
| B | VAL328 |
| B | PHE331 |
| B | GLU335 |
| B | GLU401 |
| B | VAL402 |
| B | THR403 |
| B | SER404 |
| B | ASN434 |
| B | THR436 |
| B | ALA439 |
| B | HOH905 |
| B | HOH1014 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16163389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WLE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9JJL8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9JJL8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| A | ARG313 | |
| A | GLU315 | |
| A | THR318 | |
| A | ARG327 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| B | ARG313 | |
| B | GLU315 | |
| B | THR318 | |
| B | GLU321 | |
| B | ARG327 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| A | ARG313 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ses |
| Chain | Residue | Details |
| B | ARG313 |
