Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1WFC

STRUCTURE OF APO, UNPHOSPHORYLATED, P38 MITOGEN ACTIVATED PROTEIN KINASE P38 (P38 MAP KINASE) THE MAMMALIAN HOMOLOGUE OF THE YEAST HOG1 PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0000922	cellular_component	spindle pole
A	0001502	biological_process	cartilage condensation
A	0001649	biological_process	osteoblast differentiation
A	0002021	biological_process	response to dietary excess
A	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0004708	molecular_function	MAP kinase kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0007166	biological_process	cell surface receptor signaling pathway
A	0010628	biological_process	positive regulation of gene expression
A	0010831	biological_process	positive regulation of myotube differentiation
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0030168	biological_process	platelet activation
A	0030316	biological_process	osteoclast differentiation
A	0031098	biological_process	stress-activated protein kinase signaling cascade
A	0031281	biological_process	positive regulation of cyclase activity
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032868	biological_process	response to insulin
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
A	0034774	cellular_component	secretory granule lumen
A	0035331	biological_process	negative regulation of hippo signaling
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0038066	biological_process	p38MAPK cascade
A	0042770	biological_process	signal transduction in response to DNA damage
A	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045663	biological_process	positive regulation of myoblast differentiation
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0048273	molecular_function	mitogen-activated protein kinase p38 binding
A	0051149	biological_process	positive regulation of muscle cell differentiation
A	0051403	biological_process	stress-activated MAPK cascade
A	0051525	molecular_function	NFAT protein binding
A	0060348	biological_process	bone development
A	0070935	biological_process	3'-UTR-mediated mRNA stabilization
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071223	biological_process	cellular response to lipoteichoic acid
A	0071479	biological_process	cellular response to ionizing radiation
A	0071493	biological_process	cellular response to UV-B
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0090398	biological_process	cellular senescence
A	0090400	biological_process	stress-induced premature senescence
A	0098586	biological_process	cellular response to virus
A	0098978	cellular_component	glutamatergic synapse
A	0099179	biological_process	regulation of synaptic membrane adhesion
A	0106310	molecular_function	protein serine kinase activity
A	1900015	biological_process	regulation of cytokine production involved in inflammatory response
A	1901741	biological_process	positive regulation of myoblast fusion
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK

Chain	Residue	Details
A	VAL30-LYS54

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC

Chain	Residue	Details
A	PHE59-CYS162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21444723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"PubMed","id":"15735648","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	SER154
A	ASP150

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS152
A	ASP150

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS152
A	THR185
A	ASP150

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN155
A	LYS152
A	ASP150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)