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1WB9

Crystal Structure of E. coli DNA Mismatch Repair enzyme MutS, E38T mutant, in complex with a G.T mismatch

Functional Information from GO Data
ChainGOidnamespacecontents
A0000018biological_processregulation of DNA recombination
A0000166molecular_functionnucleotide binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006298biological_processmismatch repair
A0006974biological_processDNA damage response
A0008301molecular_functionDNA binding, bending
A0016887molecular_functionATP hydrolysis activity
A0030983molecular_functionmismatched DNA binding
A0032136molecular_functionadenine/cytosine mispair binding
A0032300cellular_componentmismatch repair complex
A0042802molecular_functionidentical protein binding
A0043531molecular_functionADP binding
A0140664molecular_functionATP-dependent DNA damage sensor activity
A1990710cellular_componentMutS complex
B0000018biological_processregulation of DNA recombination
B0000166molecular_functionnucleotide binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006298biological_processmismatch repair
B0006974biological_processDNA damage response
B0008301molecular_functionDNA binding, bending
B0016887molecular_functionATP hydrolysis activity
B0030983molecular_functionmismatched DNA binding
B0032136molecular_functionadenine/cytosine mispair binding
B0032300cellular_componentmismatch repair complex
B0042802molecular_functionidentical protein binding
B0043531molecular_functionADP binding
B0140664molecular_functionATP-dependent DNA damage sensor activity
B1990710cellular_componentMutS complex
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A1802
ChainResidue
ASER621
AADP1801
AHOH2381
AHOH2411
AHOH2490
AHOH2492

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ADP A1801
ChainResidue
APRO615
AMET617
AGLY618
AGLY619
ALYS620
ASER621
ATHR622
AHIS760
AMG1802
AHOH2380
AHOH2490
AHOH2491
AHOH2492
ALEU592
APHE596
AILE597

Functional Information from PROSITE/UniProt
site_idPS00486
Number of Residues17
DetailsDNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLvLmDEIGRGTstydG
ChainResidueDetails
ASER688-GLY704

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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