Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1WA5

Structure of the Cse1:Imp-alpha:RanGTP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006913	biological_process	nucleocytoplasmic transport
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006607	biological_process	NLS-bearing protein import into nucleus
B	0006612	biological_process	protein targeting to membrane
B	0008139	molecular_function	nuclear localization sequence binding
B	0015031	biological_process	protein transport
B	0031144	biological_process	proteasome localization
B	0032991	cellular_component	protein-containing complex
B	0042564	cellular_component	NLS-dependent protein nuclear import complex
B	0044877	molecular_function	protein-containing complex binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051170	biological_process	import into nucleus
B	0061608	molecular_function	nuclear import signal receptor activity
B	0097718	molecular_function	disordered domain specific binding
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006611	biological_process	protein export from nucleus
C	0006886	biological_process	intracellular protein transport
C	0015031	biological_process	protein transport
C	0031267	molecular_function	small GTPase binding
C	0032991	cellular_component	protein-containing complex
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0051170	biological_process	import into nucleus
C	0051301	biological_process	cell division
C	0061015	biological_process	snRNA import into nucleus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	Domain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9533885","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9878368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BXQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	39
Details	Repeat: {"description":"ARM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	41
Details	Repeat: {"description":"ARM 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	46
Details	Repeat: {"description":"ARM 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	36
Details	Repeat: {"description":"ARM 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	41
Details	Repeat: {"description":"ARM 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	41
Details	Repeat: {"description":"ARM 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	44
Details	Repeat: {"description":"ARM 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	53
Details	Repeat: {"description":"ARM 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	36
Details	Repeat: {"description":"ARM 10; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00259","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8521485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	126
Details	Region: {"description":"NLS binding site 1"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	86
Details	Region: {"description":"NLS binding site 2"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	32
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	73
Details	Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	39
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	46
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	36
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	62
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	57
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	44
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	52
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	43
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	57
Details	Repeat: {"description":"HEAT 12"}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	43
Details	Repeat: {"description":"HEAT 13"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	43
Details	Repeat: {"description":"HEAT 14"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	41
Details	Repeat: {"description":"HEAT 15"}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	34
Details	Repeat: {"description":"HEAT 16"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	42
Details	Repeat: {"description":"HEAT 17"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	31
Details	Repeat: {"description":"HEAT 18"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN69

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)