1WA5
Structure of the Cse1:Imp-alpha:RanGTP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006913 | biological_process | nucleocytoplasmic transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| B | 0006612 | biological_process | protein targeting to membrane |
| B | 0008139 | molecular_function | nuclear localization sequence binding |
| B | 0015031 | biological_process | protein transport |
| B | 0031144 | biological_process | proteasome localization |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0051170 | biological_process | import into nucleus |
| B | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0097718 | molecular_function | disordered domain specific binding |
| C | 0005049 | molecular_function | nuclear export signal receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005635 | cellular_component | nuclear envelope |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006606 | biological_process | protein import into nucleus |
| C | 0006611 | biological_process | protein export from nucleus |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0007049 | biological_process | cell cycle |
| C | 0015031 | biological_process | protein transport |
| C | 0031267 | molecular_function | small GTPase binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0046827 | biological_process | positive regulation of protein export from nucleus |
| C | 0051170 | biological_process | import into nucleus |
| C | 0051301 | biological_process | cell division |
| C | 0061015 | biological_process | snRNA import into nucleus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| B | MET1 | |
| A | ASN122 | |
| A | SER150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| A | GLU36 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| A | GLY68 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Essential for GTP hydrolysis => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | GLN69 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | THR24 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS60 | |
| A | LYS99 | |
| A | LYS134 | |
| A | LYS37 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS71 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
| Chain | Residue | Details |
| A | LYS159 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS71 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS152 |
