1W7X

Factor7 - 413 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H1260

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH2166
H	HOH2176

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H1262

Chain	Residue
H	HOH2367
H	HOH2501
H	HOH2502
H	HOH2504
H	MET164
H	THR165
H	ARG230

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 H1263

Chain	Residue
H	SER244
H	GLU245
H	HOH2464
H	HOH2505
H	HOH2506
H	HOH2507
H	HOH2508
H	HOH2509
H	HOH2510
H	HOH2511
H	HOH2512

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 H1264

Chain	Residue
H	THR115
H	ASP116
H	HIS117
H	HOH2287
H	HOH2513
H	HOH2514
H	HOH2515
H	HOH2516
L	TYR133

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 L1145

Chain	Residue
H	ARG129
H	HOH2312
L	CYS102
L	SER103
L	ASP104
L	HOH2044
L	HOH2094
L	HOH2095

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 413 H1261

Chain	Residue
H	HIS57
H	ASP60
H	LYS60
H	THR99
H	SER170
H	PRO170
H	ASP189
H	SER190
H	LYS192
H	SER195
H	SER214
H	TRP215
H	GLY216
H	GLN217
H	GLY219
H	CYS220
H	GLY226
H	HOH2440
H	HOH2496
H	HOH2498
H	HOH2499
H	HOH2500

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H1258

Chain	Residue
H	SER170
H	HIS224
H	PHE225
H	HOH2376
H	HOH2379
H	HOH2439
H	HOH2493

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H1259

Chain	Residue
H	PHE59
H	ILE90
H	HOH2133
H	HOH2494
H	HOH2495

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57
H	GLY196

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	GLY193
H	HIS57

---