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1W6U

Structure of human DECR ternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0008670molecular_function2,4-dienoyl-CoA reductase (NADPH) activity
A0016491molecular_functionoxidoreductase activity
A0042802molecular_functionidentical protein binding
A0070402molecular_functionNADPH binding
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1902494cellular_componentcatalytic complex
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0008670molecular_function2,4-dienoyl-CoA reductase (NADPH) activity
B0016491molecular_functionoxidoreductase activity
B0042802molecular_functionidentical protein binding
B0070402molecular_functionNADPH binding
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1902494cellular_componentcatalytic complex
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006631biological_processfatty acid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0008670molecular_function2,4-dienoyl-CoA reductase (NADPH) activity
C0016491molecular_functionoxidoreductase activity
C0042802molecular_functionidentical protein binding
C0070402molecular_functionNADPH binding
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1902494cellular_componentcatalytic complex
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006631biological_processfatty acid metabolic process
D0006635biological_processfatty acid beta-oxidation
D0008670molecular_function2,4-dienoyl-CoA reductase (NADPH) activity
D0016491molecular_functionoxidoreductase activity
D0042802molecular_functionidentical protein binding
D0070402molecular_functionNADPH binding
D0120162biological_processpositive regulation of cold-induced thermogenesis
D1902494cellular_componentcatalytic complex
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE HXC A1330
ChainResidue
AARG119
ATYR199
ASER210
ANAP1329
AHOH2075
AHOH2132
AHOH2134
AHOH2137
DGLU326
AALA146
AGLY147
AASN148
APHE149
ASER157
AASN159
ATHR163
ATHR197

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE HXC B1331
ChainResidue
BARG91
BARG119
BGLY147
BASN148
BPHE149
BSER157
BASN159
BALA160
BTYR199
BNAP1330
BHOH2069
BHOH2147
BHOH2148
CGLU326
CHOH2126

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE HXC C1330
ChainResidue
BGLU310
BGLU326
CALA146
CGLY147
CASN148
CPHE149
CSER157
CASN159
CTHR163
CTHR197
CTYR199
CNAP1329
CHOH2047
CHOH2079
CHOH2128
CHOH2130
CHOH2131

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE HXC D1329
ChainResidue
AGLU326
DARG91
DALA146
DGLY147
DASN148
DPHE149
DSER157
DASN159
DTHR163
DILE164
DLYS214
DNAP1328
DHOH2161
DHOH2162

site_idAC5
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NAP A1329
ChainResidue
AGLY66
ATHR69
AGLY70
ALEU71
ASER90
AARG91
ALYS92
ACYS116
AASP117
AVAL118
AASN144
AALA145
AALA146
AILE195
ATHR196
ALYS214
APRO240
AGLY241
APRO242
AILE243
AHXC1330
AHOH2129
AHOH2130
AHOH2131
AHOH2132

site_idAC6
Number of Residues26
DetailsBINDING SITE FOR RESIDUE NAP B1330
ChainResidue
BASN144
BALA145
BALA146
BILE167
BILE195
BTHR196
BLYS214
BPRO240
BGLY241
BPRO242
BILE243
BHXC1331
BHOH2060
BHOH2144
BHOH2146
BGLY66
BTHR69
BGLY70
BLEU71
BSER90
BARG91
BLYS92
BCYS116
BASP117
BVAL118
BARG119

site_idAC7
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP C1329
ChainResidue
CGLY66
CTHR69
CGLY70
CLEU71
CSER90
CARG91
CLYS92
CCYS116
CASP117
CVAL118
CASN144
CALA145
CALA146
CILE195
CTHR196
CLYS214
CPRO240
CGLY241
CPRO242
CILE243
CTHR245
CHXC1330
CHOH2009
CHOH2010
CHOH2127
CHOH2128
CHOH2129

site_idAC8
Number of Residues26
DetailsBINDING SITE FOR RESIDUE NAP D1328
ChainResidue
DGLY66
DTHR69
DGLY70
DLEU71
DSER90
DARG91
DLYS92
DCYS116
DASP117
DVAL118
DASN144
DALA145
DALA146
DILE195
DTHR196
DLYS214
DPRO240
DGLY241
DPRO242
DILE243
DHXC1329
DHOH2033
DHOH2156
DHOH2157
DHOH2158
DHOH2159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255
ChainResidueDetails
ATYR199
BTYR199
CTYR199
DTYR199

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:15531764
ChainResidueDetails
AGLY66
BARG119
BPHE149
BSER157
BLYS214
BPRO240
CGLY66
CASP117
CARG119
CPHE149
CSER157
AASP117
CLYS214
CPRO240
DGLY66
DASP117
DARG119
DPHE149
DSER157
DLYS214
DPRO240
AARG119
APHE149
ASER157
ALYS214
APRO240
BGLY66
BASP117

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG91
AARG251
BARG91
BARG251
CARG91
CARG251
DARG91
DARG251

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CQ62
ChainResidueDetails
ALYS42
BLYS244
BLYS260
BLYS319
CLYS42
CLYS49
CLYS97
CLYS244
CLYS260
CLYS319
DLYS42
ALYS49
DLYS49
DLYS97
DLYS244
DLYS260
DLYS319
ALYS97
ALYS244
ALYS260
ALYS319
BLYS42
BLYS49
BLYS97

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR69
BTHR69
CTHR69
DTHR69

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9CQ62
ChainResidueDetails
ALYS73
BLYS73
CLYS73
DLYS73

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS230
BLYS230
CLYS230
DLYS230

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
AVAL207
ALYS214

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BVAL207
BLYS214

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CVAL207
CLYS214

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
DVAL207
DLYS214

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
ALYS214
ASER210

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BLYS214
BSER210

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CLYS214
CSER210

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
DLYS214
DSER210

225158

PDB entries from 2024-09-18

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