1W3N
Sulfolobus solfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with D-KDG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| A | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| A | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0009436 | biological_process | glyoxylate catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| B | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| B | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0009436 | biological_process | glyoxylate catabolic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| C | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| C | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0009436 | biological_process | glyoxylate catabolic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| D | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| D | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0009436 | biological_process | glyoxylate catabolic process |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SSH A1295 |
| Chain | Residue |
| A | PRO7 |
| A | VAL196 |
| A | ALA198 |
| A | HOH2181 |
| A | HOH2182 |
| A | PHE39 |
| A | GLY42 |
| A | THR43 |
| A | THR44 |
| A | TYR130 |
| A | TYR132 |
| A | LYS155 |
| A | THR157 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SSH B1295 |
| Chain | Residue |
| B | PRO7 |
| B | PHE39 |
| B | GLY42 |
| B | THR43 |
| B | THR44 |
| B | TYR130 |
| B | TYR132 |
| B | LYS155 |
| B | THR157 |
| B | GLY179 |
| B | VAL196 |
| B | ALA198 |
| B | HOH2225 |
| B | HOH2226 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SSH C1295 |
| Chain | Residue |
| C | PRO7 |
| C | PHE39 |
| C | GLY42 |
| C | THR43 |
| C | THR44 |
| C | TYR130 |
| C | TYR132 |
| C | LYS155 |
| C | THR157 |
| C | HOH2195 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SSH D1295 |
| Chain | Residue |
| D | PRO7 |
| D | PHE39 |
| D | GLY42 |
| D | THR43 |
| D | THR44 |
| D | TYR130 |
| D | TYR132 |
| D | LYS155 |
| D | THR157 |
| D | GLY179 |
| D | VAL196 |
| D | HOH2142 |
| D | HOH2209 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A1296 |
| Chain | Residue |
| A | GLY240 |
| A | SER241 |
| A | LEU242 |
| A | SER243 |
| A | HOH2159 |
| D | ARG106 |
| D | MET107 |
| D | SER108 |
| D | HIS111 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B1296 |
| Chain | Residue |
| B | GLY240 |
| B | SER241 |
| B | LEU242 |
| B | SER243 |
| B | HOH2203 |
| C | ARG106 |
| C | MET107 |
| C | SER108 |
| C | HIS111 |
| C | HOH2080 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D1296 |
| Chain | Residue |
| A | MET107 |
| A | SER108 |
| A | HIS111 |
| D | GLY240 |
| D | SER241 |
| D | LEU242 |
| D | SER243 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:15265860 |
| Chain | Residue | Details |
| A | LYS155 | |
| B | LYS155 | |
| C | LYS155 | |
| D | LYS155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR43 | |
| D | THR43 | |
| D | TYR130 | |
| D | LYS155 | |
| A | TYR130 | |
| A | LYS155 | |
| B | THR43 | |
| B | TYR130 | |
| B | LYS155 | |
| C | THR43 | |
| C | TYR130 | |
| C | LYS155 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Proton shuttle => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR130 | |
| B | TYR130 | |
| C | TYR130 | |
| D | TYR130 |
