Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1W3I

Sulfolobus solfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with pyruvate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
A	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009436	biological_process	glyoxylate catabolic process
A	0016829	molecular_function	lyase activity
B	0005829	cellular_component	cytosol
B	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
B	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009436	biological_process	glyoxylate catabolic process
B	0016829	molecular_function	lyase activity
C	0005829	cellular_component	cytosol
C	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
C	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009436	biological_process	glyoxylate catabolic process
C	0016829	molecular_function	lyase activity
D	0005829	cellular_component	cytosol
D	0008674	molecular_function	2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
D	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009436	biological_process	glyoxylate catabolic process
D	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PYR A1295

Chain	Residue
A	PRO7
A	PHE39
A	GLY42
A	THR43
A	THR44
A	TYR130
A	LYS155
A	VAL196

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PYR B1295

Chain	Residue
B	PHE39
B	GLY42
B	THR43
B	THR44
B	TYR130
B	LYS155
B	VAL196
B	PRO7

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PYR C1295

Chain	Residue
C	PRO7
C	PHE39
C	GLY42
C	THR43
C	THR44
C	TYR130
C	LYS155
C	VAL196

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PYR D1295

Chain	Residue
D	PRO7
D	PHE39
D	GLY42
D	THR43
D	THR44
D	TYR130
D	LYS155
D	VAL196
D	GOL1296

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A1296

Chain	Residue
A	GLY240
A	SER241
A	LEU242
A	SER243
D	ARG106
D	MET107
D	SER108
D	HIS111

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A1297

Chain	Residue
A	CYS120
A	HIS125
A	PRO126
A	CYS150
A	HOH2207

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B1296

Chain	Residue
B	GLY240
B	SER241
B	LEU242
B	SER243
C	ARG106
C	MET107
C	SER108
C	HIS111
C	HOH2081

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B1297

Chain	Residue
B	HIS125
B	PRO126
B	HOH2124
B	HOH2224

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C1296

Chain	Residue
C	THR43
C	THR44
C	TYR132
C	HOH2099
C	HOH2208
C	HOH2209

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C1297

Chain	Residue
B	ARG106
B	MET107
B	SER108
B	HIS111
C	GLY240
C	SER241
C	LEU242
C	SER243
C	ILE264

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C1298

Chain	Residue
A	LYS110
C	HIS125
C	PRO126
C	HOH2210
C	HOH2211
D	ASP268

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C1299

Chain	Residue
C	CYS120
C	HIS125
C	PRO126
C	VAL127
C	HOH2117

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D1296

Chain	Residue
D	THR43
D	THR44
D	TYR132
D	THR157
D	LEU242
D	PYR1295
D	HOH2111
D	HOH2233
D	HOH2234

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D1297

Chain	Residue
D	LEU242
D	SER243
A	MET107
A	SER108
A	HIS111
D	GLY240
D	SER241

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269\|PubMed:15265860

Chain	Residue	Details
A	LYS155
B	LYS155
C	LYS155
D	LYS155

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	THR43
D	THR43
D	TYR130
D	LYS155
A	TYR130
A	LYS155
B	THR43
B	TYR130
B	LYS155
C	THR43
C	TYR130
C	LYS155

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Proton shuttle => ECO:0000250

Chain	Residue	Details
A	TYR130
B	TYR130
C	TYR130
D	TYR130

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1fdy

Chain	Residue	Details
A	LYS155
A	THR44
A	THR43

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1fdy

Chain	Residue	Details
B	LYS155
B	THR44
B	THR43

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1fdy

Chain	Residue	Details
C	LYS155
C	THR44
C	THR43

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1fdy

Chain	Residue	Details
D	LYS155
D	THR44
D	THR43

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)