1W21
Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 43 hours at 291 K.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| C | 0004308 | molecular_function | exo-alpha-sialidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| D | 0004308 | molecular_function | exo-alpha-sialidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0016020 | cellular_component | membrane |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 |
| Chain | Residue | Details |
| A | ASP157 | |
| B | ASP1157 | |
| C | ASP2157 | |
| D | ASP3157 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 |
| Chain | Residue | Details |
| A | TYR412 | |
| B | TYR1412 | |
| C | TYR2412 | |
| D | TYR3412 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071 |
| Chain | Residue | Details |
| A | ARG124 | |
| B | ARG1378 | |
| C | ARG2124 | |
| C | ARG2158 | |
| C | GLU2283 | |
| C | ARG2299 | |
| C | ARG2378 | |
| D | ARG3124 | |
| D | ARG3158 | |
| D | GLU3283 | |
| D | ARG3299 | |
| A | ARG158 | |
| D | ARG3378 | |
| A | GLU283 | |
| A | ARG299 | |
| A | ARG378 | |
| B | ARG1124 | |
| B | ARG1158 | |
| B | GLU1283 | |
| B | ARG1299 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | ASP300 | |
| D | ASP3300 | |
| D | GLY3304 | |
| D | ASP3331 | |
| A | GLY304 | |
| A | ASP331 | |
| B | ASP1300 | |
| B | GLY1304 | |
| B | ASP1331 | |
| C | ASP2300 | |
| C | GLY2304 | |
| C | ASP2331 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | PRO354 | |
| B | PRO1354 | |
| C | PRO2354 | |
| D | PRO3354 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | ASN92 | |
| A | ASN207 | |
| B | ASN1092 | |
| B | ASN1207 | |
| C | ASN2092 | |
| C | ASN2207 | |
| D | ASN3092 | |
| D | ASN3207 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | ASN152 | |
| B | ASN1152 | |
| C | ASN2152 | |
| D | ASN3152 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071 |
| Chain | Residue | Details |
| A | ASN408 | |
| B | ASN1408 | |
| C | ASN2408 | |
| D | ASN3408 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| A | ASP157 | |
| A | GLU284 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| B | ASP1157 | |
| B | GLU1284 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| C | GLU2284 | |
| C | ASP2157 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| D | ASP3157 | |
| D | GLU3284 |
