1W20
Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004308 | molecular_function | exo-alpha-sialidase activity |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0016020 | cellular_component | membrane |
A | 0033644 | cellular_component | host cell membrane |
A | 0055036 | cellular_component | virion membrane |
B | 0004308 | molecular_function | exo-alpha-sialidase activity |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0016020 | cellular_component | membrane |
B | 0033644 | cellular_component | host cell membrane |
B | 0055036 | cellular_component | virion membrane |
C | 0004308 | molecular_function | exo-alpha-sialidase activity |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0016020 | cellular_component | membrane |
C | 0033644 | cellular_component | host cell membrane |
C | 0055036 | cellular_component | virion membrane |
D | 0004308 | molecular_function | exo-alpha-sialidase activity |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0016020 | cellular_component | membrane |
D | 0033644 | cellular_component | host cell membrane |
D | 0055036 | cellular_component | virion membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | ASP157 | |
B | ASP1157 | |
C | ASP2157 | |
D | ASP3157 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | TYR412 | |
B | TYR1412 | |
C | TYR2412 | |
D | TYR3412 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | ARG124 | |
B | ARG1378 | |
C | ARG2124 | |
C | ARG2158 | |
C | GLU2283 | |
C | ARG2299 | |
C | ARG2378 | |
D | ARG3124 | |
D | ARG3158 | |
D | GLU3283 | |
D | ARG3299 | |
A | ARG158 | |
D | ARG3378 | |
A | GLU283 | |
A | ARG299 | |
A | ARG378 | |
B | ARG1124 | |
B | ARG1158 | |
B | GLU1283 | |
B | ARG1299 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
Chain | Residue | Details |
A | ASP300 | |
D | ASP3300 | |
D | GLY3304 | |
D | ASP3331 | |
A | GLY304 | |
A | ASP331 | |
B | ASP1300 | |
B | GLY1304 | |
B | ASP1331 | |
C | ASP2300 | |
C | GLY2304 | |
C | ASP2331 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
Chain | Residue | Details |
A | PRO354 | |
B | PRO1354 | |
C | PRO2354 | |
D | PRO3354 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7 |
Chain | Residue | Details |
A | ASN92 | |
A | ASN207 | |
B | ASN1092 | |
B | ASN1207 | |
C | ASN2092 | |
C | ASN2207 | |
D | ASN3092 | |
D | ASN3207 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
Chain | Residue | Details |
A | ASN152 | |
B | ASN1152 | |
C | ASN2152 | |
D | ASN3152 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071 |
Chain | Residue | Details |
A | ASN408 | |
B | ASN1408 | |
C | ASN2408 | |
D | ASN3408 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
A | ASP157 | |
A | GLU284 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
B | ASP1157 | |
B | GLU1284 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
C | GLU2284 | |
C | ASP2157 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a4g |
Chain | Residue | Details |
D | ASP3157 | |
D | GLU3284 |