1W0S
Solution structure of trimeric form of properdin by X-ray solution scattering and analytical ultracentrifugation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0006955 | biological_process | immune response |
| A | 0006956 | biological_process | complement activation |
| A | 0006957 | biological_process | complement activation, alternative pathway |
| A | 0030141 | cellular_component | secretory granule |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0045087 | biological_process | innate immune response |
| A | 0045958 | biological_process | positive regulation of complement activation, alternative pathway |
| A | 0050778 | biological_process | positive regulation of immune response |
| A | 0050821 | biological_process | protein stabilization |
| A | 0098548 | cellular_component | cytoplasmic side of Golgi membrane |
| A | 1903028 | biological_process | positive regulation of opsonization |
| A | 1904724 | cellular_component | tertiary granule lumen |
| B | 0002376 | biological_process | immune system process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0006955 | biological_process | immune response |
| B | 0006956 | biological_process | complement activation |
| B | 0006957 | biological_process | complement activation, alternative pathway |
| B | 0030141 | cellular_component | secretory granule |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0045087 | biological_process | innate immune response |
| B | 0045958 | biological_process | positive regulation of complement activation, alternative pathway |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050821 | biological_process | protein stabilization |
| B | 0098548 | cellular_component | cytoplasmic side of Golgi membrane |
| B | 1903028 | biological_process | positive regulation of opsonization |
| B | 1904724 | cellular_component | tertiary granule lumen |
| C | 0002376 | biological_process | immune system process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0006955 | biological_process | immune response |
| C | 0006956 | biological_process | complement activation |
| C | 0006957 | biological_process | complement activation, alternative pathway |
| C | 0030141 | cellular_component | secretory granule |
| C | 0035580 | cellular_component | specific granule lumen |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0045087 | biological_process | innate immune response |
| C | 0045958 | biological_process | positive regulation of complement activation, alternative pathway |
| C | 0050778 | biological_process | positive regulation of immune response |
| C | 0050821 | biological_process | protein stabilization |
| C | 0098548 | cellular_component | cytoplasmic side of Golgi membrane |
| C | 1903028 | biological_process | positive regulation of opsonization |
| C | 1904724 | cellular_component | tertiary granule lumen |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 144 |
| Details | Domain: {"description":"TSP type-1 0","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 171 |
| Details | Domain: {"description":"TSP type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 165 |
| Details | Domain: {"description":"TSP type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 186 |
| Details | Domain: {"description":"TSP type-1 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 168 |
| Details | Domain: {"description":"TSP type-1 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 186 |
| Details | Domain: {"description":"TSP type-1 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 249 |
| Details | Domain: {"description":"TSP type-1 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 57 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with Complement C3 beta chain","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Glycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"10878002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | Glycosylation: {"description":"O-linked (Fuc...) threonine","evidences":[{"source":"PubMed","id":"12096136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"O-linked (Fuc...) serine","evidences":[{"source":"PubMed","id":"12096136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
