Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1W0M

Triosephosphate isomerase from Thermoproteus tenax

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016853	molecular_function	isomerase activity
F	0019563	biological_process	glycerol catabolic process
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016853	molecular_function	isomerase activity
G	0019563	biological_process	glycerol catabolic process
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016853	molecular_function	isomerase activity
H	0019563	biological_process	glycerol catabolic process
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 A1226

Chain	Residue
A	ILE146
A	HOH2089
A	HOH2101
A	HOH2102
A	GLY147
A	ALA180
A	GLY181
A	LEU201
A	ALA202
A	SER203
A	HOH2072
A	HOH2088

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 B1226

Chain	Residue
B	ILE146
B	GLY147
B	ALA180
B	GLY181
B	LEU201
B	ALA202
B	SER203
B	HOH2009
B	HOH2090
B	HOH2095
B	HOH2096
B	HOH2097

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 C1226

Chain	Residue
C	LYS11
C	ILE146
C	GLY147
C	GLY181
C	LEU201
C	ALA202
C	SER203
C	HOH2109
C	HOH2110
C	HOH2137
C	HOH2138
C	HOH2139

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 D1226

Chain	Residue
D	LYS11
D	ILE146
D	GLY147
D	GLY181
D	LEU201
D	ALA202
D	SER203
D	HOH2078
D	HOH2094
D	HOH2108
D	HOH2109
D	HOH2110

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 E1226

Chain	Residue
E	LYS11
E	ILE146
E	GLY147
E	GLY181
E	LEU201
E	ALA202
E	SER203
E	HOH2073
E	HOH2086
E	HOH2087
E	HOH2088
E	HOH2089

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 F1225

Chain	Residue
F	ILE146
F	GLY147
F	GLY181
F	ALA202
F	SER203
F	HOH2005
F	HOH2058
F	HOH2060
F	HOH2062

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 G1224

Chain	Residue
G	ILE146
G	GLY147
G	ALA180
G	GLY181
G	LEU201
G	ALA202
G	SER203
G	HOH2045
G	HOH2047

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 H1226

Chain	Residue
H	ILE146
H	GLY147
H	GLY181
H	LEU201
H	ALA202
H	SER203
H	HOH2045
H	HOH2052
H	HOH2054
H	HOH2058
H	HOH2059

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AVEPPELIGTG

Chain	Residue	Details
A	ALA139-GLY149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15342242","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
A	GLU141
A	LYS11
A	GLY147
A	HIS93
A	ASN9

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
B	GLU141
B	LYS11
B	GLY147
B	HIS93
B	ASN9

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
C	GLU141
C	LYS11
C	GLY147
C	HIS93
C	ASN9

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
D	GLU141
D	LYS11
D	GLY147
D	HIS93
D	ASN9

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
E	GLU141
E	LYS11
E	GLY147
E	HIS93
E	ASN9

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
F	GLU141
F	LYS11
F	GLY147
F	HIS93
F	ASN9

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
G	GLU141
G	LYS11
G	GLY147
G	HIS93
G	ASN9

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
H	GLU141
H	LYS11
H	GLY147
H	HIS93
H	ASN9

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)