1W0H

Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0003676	molecular_function	nucleic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A1000

Chain	Residue
A	ASP134
A	ASP234
A	MG1001
A	AMP1002
A	HOH2020
A	HOH2242

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A1001

Chain	Residue
A	MG1000
A	AMP1002
A	ASP134
A	GLU136
A	ASP298

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site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE AMP A1002

Chain	Residue
A	ASP134
A	PHE135
A	GLU136
A	ALA137
A	THR138
A	CYS139
A	PHE185
A	ASP234
A	PHE238
A	HIS293
A	ASP298
A	MG1000
A	MG1001
A	HOH2020
A	HOH2035
A	HOH2365
A	HOH2366
A	HOH2367
A	HOH2370

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 15451662

Chain	Residue	Details
A	GLU136
A	HIS293

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
A	THR138	metal ligand
A	GLU140	electrostatic stabiliser, metal ligand, proton acceptor
A	GLN242	metal ligand
A	GLY313	electrostatic stabiliser, proton acceptor
A	ILE318	metal ligand

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