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1W0D

The high resolution structure of Mycobacterium tuberculosis LeuB (Rv2995c)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003862molecular_function3-isopropylmalate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0008652biological_processamino acid biosynthetic process
A0009082biological_processbranched-chain amino acid biosynthetic process
A0009098biological_processL-leucine biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
B0000287molecular_functionmagnesium ion binding
B0003862molecular_function3-isopropylmalate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0008652biological_processamino acid biosynthetic process
B0009082biological_processbranched-chain amino acid biosynthetic process
B0009098biological_processL-leucine biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0046872molecular_functionmetal ion binding
B0051287molecular_functionNAD binding
C0000287molecular_functionmagnesium ion binding
C0003862molecular_function3-isopropylmalate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0008652biological_processamino acid biosynthetic process
C0009082biological_processbranched-chain amino acid biosynthetic process
C0009098biological_processL-leucine biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0046872molecular_functionmetal ion binding
C0051287molecular_functionNAD binding
D0000287molecular_functionmagnesium ion binding
D0003862molecular_function3-isopropylmalate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0008652biological_processamino acid biosynthetic process
D0009082biological_processbranched-chain amino acid biosynthetic process
D0009098biological_processL-leucine biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0046872molecular_functionmetal ion binding
D0051287molecular_functionNAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 D1337
ChainResidue
CASN180
CHIS209
DSER75
DGLY76
DGLU79

Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLFGDIiTDlaAavc.GGIGL
ChainResidueDetails
AASN231-LEU250

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsSite: {"description":"Important for catalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
AASP211
ALYS178
BTYR128

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
ATYR128
BASP211
BLYS178

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
DTYR128
CASP211
CLYS178

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
CTYR128
DASP211
DLYS178

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PDB entries from 2025-07-23

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