1W0D

The high resolution structure of Mycobacterium tuberculosis LeuB (Rv2995c)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0009098	biological_process	L-leucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0009098	biological_process	L-leucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0009098	biological_process	L-leucine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0009098	biological_process	L-leucine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D1337

Chain	Residue
C	ASN180
C	HIS209
D	SER75
D	GLY76
D	GLU79

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Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLFGDIiTDlaAavc.GGIGL

Chain	Residue	Details
A	ASN231-LEU250

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01035

Chain	Residue	Details
A	ASP235
A	ASP239
A	GLY271
B	ARG87
B	ARG97
B	ARG121
B	ASP211
B	ASP235
B	ASP239
B	GLY271
C	ARG87
C	ARG97
C	ARG121
C	ASP211
C	ASP235
C	ASP239
C	GLY271
D	ARG87
D	ARG97
D	ARG121
D	ASP211
D	ASP235
D	ASP239
D	GLY271
A	ARG87
A	ARG97
A	ARG121
A	ASP211

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Important for catalysis => ECO:0000255|HAMAP-Rule:MF_01035

Chain	Residue	Details
A	TYR128
A	LYS178
B	TYR128
B	LYS178
C	TYR128
C	LYS178
D	TYR128
D	LYS178

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