1VZ8
Ornithine Acetyltransferase (ORF6 Gene Product - Clavulanic Acid Biosynthesis) from Streptomyces clavuligerus (SeMet structure)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004042 | molecular_function | L-glutamate N-acetyltransferase activity |
| A | 0004358 | molecular_function | L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0006592 | biological_process | ornithine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033050 | biological_process | clavulanic acid biosynthetic process |
| B | 0004042 | molecular_function | L-glutamate N-acetyltransferase activity |
| B | 0004358 | molecular_function | L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0006592 | biological_process | ornithine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033050 | biological_process | clavulanic acid biosynthetic process |
| C | 0004042 | molecular_function | L-glutamate N-acetyltransferase activity |
| C | 0004358 | molecular_function | L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0006592 | biological_process | ornithine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0033050 | biological_process | clavulanic acid biosynthetic process |
| D | 0004042 | molecular_function | L-glutamate N-acetyltransferase activity |
| D | 0004358 | molecular_function | L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006526 | biological_process | L-arginine biosynthetic process |
| D | 0006592 | biological_process | ornithine biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0033050 | biological_process | clavulanic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1391 |
| Chain | Residue |
| A | THR111 |
| A | GLY112 |
| A | THR148 |
| A | LYS170 |
| A | THR181 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1392 |
| Chain | Residue |
| A | ARG386 |
| A | HIS297 |
| A | THR381 |
| A | GLU382 |
| A | GLY383 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A1393 |
| Chain | Residue |
| A | ARG191 |
| A | GLY233 |
| A | GLU234 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1394 |
| Chain | Residue |
| B | THR111 |
| B | GLY112 |
| B | THR148 |
| B | LYS170 |
| B | THR181 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C1394 |
| Chain | Residue |
| C | THR111 |
| C | GLY112 |
| C | THR148 |
| C | LYS170 |
| C | THR181 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D1391 |
| Chain | Residue |
| D | THR111 |
| D | GLY112 |
| D | THR148 |
| D | LYS170 |
| D | THR181 |
| D | HOH2008 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21796301","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cleavage; by autolysis"} |
| Chain | Residue | Details |
