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1VS0

Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A

Functional Information from GO Data
ChainGOidnamespacecontents
A0003910molecular_functionDNA ligase (ATP) activity
A0005524molecular_functionATP binding
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
B0003910molecular_functionDNA ligase (ATP) activity
B0005524molecular_functionATP binding
B0006281biological_processDNA repair
B0006310biological_processDNA recombination
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 9001
ChainResidue
BAPK481
BASP483
BASP522
BGLU613

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 9002
ChainResidue
AAPK481
AASP483
AASP522
AGLU613

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 9003
ChainResidue
BHIS493
BGLU727
BCL9008
BASP492

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 9004
ChainResidue
AASP492
AHIS493
AGLU727
ACL9007

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 9005
ChainResidue
AALA463
AAPK481
ALYS635
AHOH9163

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 9006
ChainResidue
BALA463
BAPK481
BHOH9118
BHOH9188

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL A 9007
ChainResidue
AASP492
AHIS493
AGLU727
AARG748
AZN9004
AHOH9220

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CL B 9008
ChainResidue
BASP492
BHIS493
BHIS524
BGLU727
BARG748
BZN9003
BHOH9178

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 9009
ChainResidue
AGLU454
AASP456
AASP750
BHIS699
BASP701

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: N6-AMP-lysine intermediate; for ligase activity => ECO:0000269|PubMed:12215643, ECO:0000269|PubMed:16476729
ChainResidueDetails
AAPK481
BAPK481

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:17174332
ChainResidueDetails
AASP483
AGLU613
BASP483
BGLU613

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PDB entries from 2024-11-06

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