1VRC

Complex of enzyme IIAmannose and the histidine-containing phosphocarrier protein HPr from escherichia coli nmr, restrained regularized mean structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008643	biological_process	carbohydrate transport
A	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
A	0016020	cellular_component	membrane
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0005737	cellular_component	cytoplasm
B	0008643	biological_process	carbohydrate transport
B	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
B	0016020	cellular_component	membrane
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008047	molecular_function	enzyme activator activity
C	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
C	0016775	molecular_function	phosphotransferase activity, nitrogenous group as acceptor
C	0030234	molecular_function	enzyme regulator activity
C	0043609	biological_process	regulation of carbon utilization
C	0045152	molecular_function	antisigma factor binding
C	0045819	biological_process	positive regulation of glycogen catabolic process
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008047	molecular_function	enzyme activator activity
D	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
D	0016775	molecular_function	phosphotransferase activity, nitrogenous group as acceptor
D	0030234	molecular_function	enzyme regulator activity
D	0043609	biological_process	regulation of carbon utilization
D	0045152	molecular_function	antisigma factor binding
D	0045819	biological_process	positive regulation of glycogen catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00369
Number of Residues	8
Details	PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GLHTRPAA

Chain	Residue	Details
C	GLY213-ALA220

---

site_id	PS00589
Number of Residues	16
Details	PTS_HPR_SER PTS HPR domain serine phosphorylation site signature. GKsASaKSLFKLQtLG

Chain	Residue	Details
C	GLY239-GLY254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	244
Details	Domain: {"description":"PTS EIIA type-4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18270202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8676384","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Tele-phosphohistidine intermediate; for EIIA activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15788390","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18270202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8262947","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8676384","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Involved in the phosphoryl transfer between H-10 and H-175","evidences":[{"source":"PubMed","id":"8262947","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphohistidine; by HPr","evidences":[{"source":"PubMed","id":"2681202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8262947","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	168
Details	Domain: {"description":"HPr","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00681","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2261470","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---