1VR7
Crystal structure of S-adenosylmethionine decarboxylase proenzyme (TM0655) from THERMOTOGA MARITIMA at 1.2 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0008295 | biological_process | spermidine biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0008295 | biological_process | spermidine biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 131 |
Chain | Residue |
A | VAL9 |
A | GLU11 |
A | HIS106 |
B | HIS110 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000250 |
Chain | Residue | Details |
A | SER63 | |
B | SER63 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor; for processing activity => ECO:0000305|PubMed:15150268 |
Chain | Residue | Details |
A | HIS68 | |
B | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor; for catalytic activity => ECO:0000305|PubMed:15150268 |
Chain | Residue | Details |
A | CYS83 | |
B | CYS83 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Cleavage (non-hydrolytic); by autolysis => ECO:0000305 |
Chain | Residue | Details |
A | GLU62 | |
B | GLU62 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Pyruvic acid (Ser); by autocatalysis => ECO:0000305 |
Chain | Residue | Details |
A | SER63 | |
B | SER63 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 225 |
Chain | Residue | Details |
A | SER55 | electrostatic stabiliser |
A | GLU62 | covalently attached, electrophile, hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
A | SER63 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleophile, polar interaction, proton donor |
A | HIS68 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | CYS83 | hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 225 |
Chain | Residue | Details |
B | SER55 | electrostatic stabiliser |
B | GLU62 | covalently attached, electrophile, hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
B | SER63 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleophile, polar interaction, proton donor |
B | HIS68 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | CYS83 | hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor |