1VPA
Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TM1393) from Thermotoga maritima at 2.67 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005829 | cellular_component | cytosol |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
A | 0070567 | molecular_function | cytidylyltransferase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005829 | cellular_component | cytosol |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016779 | molecular_function | nucleotidyltransferase activity |
B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
B | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 600 |
Chain | Residue |
A | CTP500 |
A | HOH749 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 600 |
Chain | Residue |
B | CTP500 |
site_id | AC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE CTP A 500 |
Chain | Residue |
A | GLU13 |
A | ARG14 |
A | LYS21 |
A | GLY76 |
A | ASP77 |
A | THR78 |
A | ARG79 |
A | SER82 |
A | ASP102 |
A | SER103 |
A | ALA104 |
A | LYS201 |
A | MG600 |
A | ACY700 |
A | HOH705 |
A | HOH751 |
A | HOH762 |
A | HOH769 |
A | LEU7 |
A | ALA8 |
A | ALA9 |
A | GLY10 |
A | LYS11 |
A | GLY12 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE CTP B 500 |
Chain | Residue |
B | LEU7 |
B | ALA8 |
B | ALA9 |
B | GLY10 |
B | LYS11 |
B | GLY12 |
B | GLU13 |
B | ARG14 |
B | LYS21 |
B | GLY76 |
B | ASP77 |
B | THR78 |
B | ARG79 |
B | SER82 |
B | ASP102 |
B | SER103 |
B | ALA104 |
B | LYS201 |
B | MG600 |
B | ACY700 |
B | HOH703 |
B | HOH719 |
B | HOH725 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE ACY A 700 |
Chain | Residue |
A | ARG14 |
A | LYS201 |
A | CTP500 |
A | HOH734 |
A | HOH749 |
B | SER133 |
B | ASP134 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACY B 700 |
Chain | Residue |
A | SER133 |
A | ASP134 |
B | ARG14 |
B | LYS201 |
B | CTP500 |
B | HOH737 |
Functional Information from PROSITE/UniProt
site_id | PS01295 |
Number of Residues | 8 |
Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDSAR |
Chain | Residue | Details |
A | VAL98-ARG105 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00108 |
Chain | Residue | Details |
A | ARG14 | |
A | LYS21 | |
B | ARG14 | |
B | LYS21 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108 |
Chain | Residue | Details |
A | ARG149 | |
A | LYS201 | |
B | ARG149 | |
B | LYS201 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hv9 |
Chain | Residue | Details |
A | ARG14 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hv9 |
Chain | Residue | Details |
B | ARG14 |