1VPA
Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TM1393) from Thermotoga maritima at 2.67 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| A | 0070567 | molecular_function | cytidylyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| B | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 600 |
| Chain | Residue |
| A | CTP500 |
| A | HOH749 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG B 600 |
| Chain | Residue |
| B | CTP500 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CTP A 500 |
| Chain | Residue |
| A | GLU13 |
| A | ARG14 |
| A | LYS21 |
| A | GLY76 |
| A | ASP77 |
| A | THR78 |
| A | ARG79 |
| A | SER82 |
| A | ASP102 |
| A | SER103 |
| A | ALA104 |
| A | LYS201 |
| A | MG600 |
| A | ACY700 |
| A | HOH705 |
| A | HOH751 |
| A | HOH762 |
| A | HOH769 |
| A | LEU7 |
| A | ALA8 |
| A | ALA9 |
| A | GLY10 |
| A | LYS11 |
| A | GLY12 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE CTP B 500 |
| Chain | Residue |
| B | LEU7 |
| B | ALA8 |
| B | ALA9 |
| B | GLY10 |
| B | LYS11 |
| B | GLY12 |
| B | GLU13 |
| B | ARG14 |
| B | LYS21 |
| B | GLY76 |
| B | ASP77 |
| B | THR78 |
| B | ARG79 |
| B | SER82 |
| B | ASP102 |
| B | SER103 |
| B | ALA104 |
| B | LYS201 |
| B | MG600 |
| B | ACY700 |
| B | HOH703 |
| B | HOH719 |
| B | HOH725 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY A 700 |
| Chain | Residue |
| A | ARG14 |
| A | LYS201 |
| A | CTP500 |
| A | HOH734 |
| A | HOH749 |
| B | SER133 |
| B | ASP134 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 700 |
| Chain | Residue |
| A | SER133 |
| A | ASP134 |
| B | ARG14 |
| B | LYS201 |
| B | CTP500 |
| B | HOH737 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDSAR |
| Chain | Residue | Details |
| A | VAL98-ARG105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00108 |
| Chain | Residue | Details |
| A | ARG14 | |
| A | LYS21 | |
| B | ARG14 | |
| B | LYS21 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108 |
| Chain | Residue | Details |
| A | ARG149 | |
| A | LYS201 | |
| B | ARG149 | |
| B | LYS201 |
