1VM8

Crystal structure of UDP-N-acetylglucosamine pyrophosphorylase (Agx2) from Mus musculus at 2.50 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0003977	molecular_function	UDP-N-acetylglucosamine diphosphorylase activity
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006047	biological_process	UDP-N-acetylglucosamine metabolic process
A	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0016779	molecular_function	nucleotidyltransferase activity
A	0030246	molecular_function	carbohydrate binding
A	0032481	biological_process	positive regulation of type I interferon production
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0052630	molecular_function	UDP-N-acetylgalactosamine diphosphorylase activity
A	0070569	molecular_function	uridylyltransferase activity
A	0140374	biological_process	antiviral innate immune response
A	0141090	molecular_function	protein serine pyrophosphorylase activity
B	0002376	biological_process	immune system process
B	0003977	molecular_function	UDP-N-acetylglucosamine diphosphorylase activity
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006047	biological_process	UDP-N-acetylglucosamine metabolic process
B	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0016779	molecular_function	nucleotidyltransferase activity
B	0030246	molecular_function	carbohydrate binding
B	0032481	biological_process	positive regulation of type I interferon production
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0052630	molecular_function	UDP-N-acetylgalactosamine diphosphorylase activity
B	0070569	molecular_function	uridylyltransferase activity
B	0140374	biological_process	antiviral innate immune response
B	0141090	molecular_function	protein serine pyrophosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 523

Chain	Residue
B	ARG9
B	ASN41
B	PHE42

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 524

Chain	Residue
B	ARG422
B	HIS423

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 525

Chain	Residue
B	LYS180

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 526

Chain	Residue
B	GLU502
B	HOH552

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 523

Chain	Residue
A	PHE42
A	ARG9

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 527

Chain	Residue
B	LYS390

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 528

Chain	Residue
B	LEU77
B	ASP83
B	LYS271
B	HOH584

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q16222","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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