Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1VLQ

Crystal structure of Acetyl xylan esterase (TM0077) from Thermotoga maritima at 2.10 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0005976	biological_process	polysaccharide metabolic process
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0030245	biological_process	cellulose catabolic process
A	0045491	biological_process	xylan metabolic process
A	0046555	molecular_function	acetylxylan esterase activity
A	0046872	molecular_function	metal ion binding
A	0047739	molecular_function	cephalosporin-C deacetylase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	1901266	biological_process	cephalosporin C metabolic process
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0005976	biological_process	polysaccharide metabolic process
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0030245	biological_process	cellulose catabolic process
B	0045491	biological_process	xylan metabolic process
B	0046555	molecular_function	acetylxylan esterase activity
B	0046872	molecular_function	metal ion binding
B	0047739	molecular_function	cephalosporin-C deacetylase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	1901266	biological_process	cephalosporin C metabolic process
C	0005509	molecular_function	calcium ion binding
C	0005737	cellular_component	cytoplasm
C	0005976	biological_process	polysaccharide metabolic process
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0030245	biological_process	cellulose catabolic process
C	0045491	biological_process	xylan metabolic process
C	0046555	molecular_function	acetylxylan esterase activity
C	0046872	molecular_function	metal ion binding
C	0047739	molecular_function	cephalosporin-C deacetylase activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
C	1901266	biological_process	cephalosporin C metabolic process
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0005976	biological_process	polysaccharide metabolic process
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0030245	biological_process	cellulose catabolic process
D	0045491	biological_process	xylan metabolic process
D	0046555	molecular_function	acetylxylan esterase activity
D	0046872	molecular_function	metal ion binding
D	0047739	molecular_function	cephalosporin-C deacetylase activity
D	0052689	molecular_function	carboxylic ester hydrolase activity
D	1901266	biological_process	cephalosporin C metabolic process
E	0005509	molecular_function	calcium ion binding
E	0005737	cellular_component	cytoplasm
E	0005976	biological_process	polysaccharide metabolic process
E	0016788	molecular_function	hydrolase activity, acting on ester bonds
E	0030245	biological_process	cellulose catabolic process
E	0045491	biological_process	xylan metabolic process
E	0046555	molecular_function	acetylxylan esterase activity
E	0046872	molecular_function	metal ion binding
E	0047739	molecular_function	cephalosporin-C deacetylase activity
E	0052689	molecular_function	carboxylic ester hydrolase activity
E	1901266	biological_process	cephalosporin C metabolic process
F	0005509	molecular_function	calcium ion binding
F	0005737	cellular_component	cytoplasm
F	0005976	biological_process	polysaccharide metabolic process
F	0016788	molecular_function	hydrolase activity, acting on ester bonds
F	0030245	biological_process	cellulose catabolic process
F	0045491	biological_process	xylan metabolic process
F	0046555	molecular_function	acetylxylan esterase activity
F	0046872	molecular_function	metal ion binding
F	0047739	molecular_function	cephalosporin-C deacetylase activity
F	0052689	molecular_function	carboxylic ester hydrolase activity
F	1901266	biological_process	cephalosporin C metabolic process
G	0005509	molecular_function	calcium ion binding
G	0005737	cellular_component	cytoplasm
G	0005976	biological_process	polysaccharide metabolic process
G	0016788	molecular_function	hydrolase activity, acting on ester bonds
G	0030245	biological_process	cellulose catabolic process
G	0045491	biological_process	xylan metabolic process
G	0046555	molecular_function	acetylxylan esterase activity
G	0046872	molecular_function	metal ion binding
G	0047739	molecular_function	cephalosporin-C deacetylase activity
G	0052689	molecular_function	carboxylic ester hydrolase activity
G	1901266	biological_process	cephalosporin C metabolic process
H	0005509	molecular_function	calcium ion binding
H	0005737	cellular_component	cytoplasm
H	0005976	biological_process	polysaccharide metabolic process
H	0016788	molecular_function	hydrolase activity, acting on ester bonds
H	0030245	biological_process	cellulose catabolic process
H	0045491	biological_process	xylan metabolic process
H	0046555	molecular_function	acetylxylan esterase activity
H	0046872	molecular_function	metal ion binding
H	0047739	molecular_function	cephalosporin-C deacetylase activity
H	0052689	molecular_function	carboxylic ester hydrolase activity
H	1901266	biological_process	cephalosporin C metabolic process
I	0005509	molecular_function	calcium ion binding
I	0005737	cellular_component	cytoplasm
I	0005976	biological_process	polysaccharide metabolic process
I	0016788	molecular_function	hydrolase activity, acting on ester bonds
I	0030245	biological_process	cellulose catabolic process
I	0045491	biological_process	xylan metabolic process
I	0046555	molecular_function	acetylxylan esterase activity
I	0046872	molecular_function	metal ion binding
I	0047739	molecular_function	cephalosporin-C deacetylase activity
I	0052689	molecular_function	carboxylic ester hydrolase activity
I	1901266	biological_process	cephalosporin C metabolic process
J	0005509	molecular_function	calcium ion binding
J	0005737	cellular_component	cytoplasm
J	0005976	biological_process	polysaccharide metabolic process
J	0016788	molecular_function	hydrolase activity, acting on ester bonds
J	0030245	biological_process	cellulose catabolic process
J	0045491	biological_process	xylan metabolic process
J	0046555	molecular_function	acetylxylan esterase activity
J	0046872	molecular_function	metal ion binding
J	0047739	molecular_function	cephalosporin-C deacetylase activity
J	0052689	molecular_function	carboxylic ester hydrolase activity
J	1901266	biological_process	cephalosporin C metabolic process
K	0005509	molecular_function	calcium ion binding
K	0005737	cellular_component	cytoplasm
K	0005976	biological_process	polysaccharide metabolic process
K	0016788	molecular_function	hydrolase activity, acting on ester bonds
K	0030245	biological_process	cellulose catabolic process
K	0045491	biological_process	xylan metabolic process
K	0046555	molecular_function	acetylxylan esterase activity
K	0046872	molecular_function	metal ion binding
K	0047739	molecular_function	cephalosporin-C deacetylase activity
K	0052689	molecular_function	carboxylic ester hydrolase activity
K	1901266	biological_process	cephalosporin C metabolic process
L	0005509	molecular_function	calcium ion binding
L	0005737	cellular_component	cytoplasm
L	0005976	biological_process	polysaccharide metabolic process
L	0016788	molecular_function	hydrolase activity, acting on ester bonds
L	0030245	biological_process	cellulose catabolic process
L	0045491	biological_process	xylan metabolic process
L	0046555	molecular_function	acetylxylan esterase activity
L	0046872	molecular_function	metal ion binding
L	0047739	molecular_function	cephalosporin-C deacetylase activity
L	0052689	molecular_function	carboxylic ester hydrolase activity
L	1901266	biological_process	cephalosporin C metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 326

Chain	Residue
A	ASP23
A	ASP151
A	PRO152
A	ARG153
A	ARG248
A	TYR252

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:22411095

Chain	Residue	Details
A	SER188
J	SER188
K	SER188
L	SER188
B	SER188
C	SER188
D	SER188
E	SER188
F	SER188
G	SER188
H	SER188
I	SER188

site_id	SWS_FT_FI2
Number of Residues	24
Details	ACT_SITE: Charge relay system => ECO:0000250\|UniProtKB:P94388

Chain	Residue	Details
A	ASP274
E	HIS303
F	ASP274
F	HIS303
G	ASP274
G	HIS303
H	ASP274
H	HIS303
I	ASP274
I	HIS303
J	ASP274
A	HIS303
J	HIS303
K	ASP274
K	HIS303
L	ASP274
L	HIS303
B	ASP274
B	HIS303
C	ASP274
C	HIS303
D	ASP274
D	HIS303
E	ASP274

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P94388

Chain	Residue	Details
A	TYR92
J	TYR92
K	TYR92
L	TYR92
B	TYR92
C	TYR92
D	TYR92
E	TYR92
F	TYR92
G	TYR92
H	TYR92
I	TYR92

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: covalent => ECO:0000269\|PubMed:22411095

Chain	Residue	Details
A	SER188
J	SER188
K	SER188
L	SER188
B	SER188
C	SER188
D	SER188
E	SER188
F	SER188
G	SER188
H	SER188
I	SER188

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
A	ASP274
A	HIS303
A	SER188

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
J	ASP274
J	HIS303
J	SER188

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
K	ASP274
K	HIS303
K	SER188

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
L	ASP274
L	HIS303
L	SER188

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
B	ASP274
B	HIS303
B	SER188

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
C	ASP274
C	HIS303
C	SER188

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
D	ASP274
D	HIS303
D	SER188

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
E	ASP274
E	HIS303
E	SER188

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
F	ASP274
F	HIS303
F	SER188

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
G	ASP274
G	HIS303
G	SER188

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
H	ASP274
H	HIS303
H	SER188

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1jkm

Chain	Residue	Details
I	ASP274
I	HIS303
I	SER188

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)