1VLP

Crystal structure of a putative nicotinate phosphoribosyltransferase (yor209c, npt1) from saccharomyces cerevisiae at 1.75 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000183	biological_process	rDNA heterochromatin formation
A	0000781	cellular_component	chromosome, telomeric region
A	0004516	molecular_function	nicotinate phosphoribosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
A	0019358	biological_process	nicotinate nucleotide salvage
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0000183	biological_process	rDNA heterochromatin formation
B	0000781	cellular_component	chromosome, telomeric region
B	0004516	molecular_function	nicotinate phosphoribosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
B	0019358	biological_process	nicotinate nucleotide salvage
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0000183	biological_process	rDNA heterochromatin formation
C	0000781	cellular_component	chromosome, telomeric region
C	0004516	molecular_function	nicotinate phosphoribosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD+ biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016874	molecular_function	ligase activity
C	0019358	biological_process	nicotinate nucleotide salvage
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0000183	biological_process	rDNA heterochromatin formation
D	0000781	cellular_component	chromosome, telomeric region
D	0004516	molecular_function	nicotinate phosphoribosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD+ biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
D	0019358	biological_process	nicotinate nucleotide salvage
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0031509	biological_process	subtelomeric heterochromatin formation
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 500

Chain	Residue
A	SER327
A	SER329
A	GLY354
A	THR355
A	HOH569
A	HOH574
A	HOH599

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 500

Chain	Residue
B	GLY354
B	THR355
B	HOH649
B	HOH653
B	SER327
B	SER329

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 500

Chain	Residue
C	SER327
C	SER329
C	GLY354
C	THR355
C	HOH515
C	HOH526
C	HOH613
C	HOH784

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 500

Chain	Residue
D	SER327
D	SER329
D	GLY354
D	THR355
D	HOH544
D	HOH556
D	HOH637

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 501

Chain	Residue
C	TYR36
C	ASN38
C	LEU117
C	HOH534
C	HOH694

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	TYR36
A	ASN38
A	LEU117
A	HOH633

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 501

Chain	Residue
B	TYR36
B	ASN38
B	LEU117
B	HOH524
B	HOH654

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 502

Chain	Residue
A	THR31
A	VAL32
A	THR33
A	SER122
A	GLU382
A	ASN384
A	GLY385
B	LYS111

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 502

Chain	Residue
C	THR275
C	ASP276
C	ASP393
C	TYR414
C	THR415
C	HOH719

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 503

Chain	Residue
A	LYS111
B	THR31
B	VAL32
B	THR33
B	SER122
B	GLU382
B	ASN384
B	GLY385

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MES A 502

Chain	Residue
A	ASP204
B	LYS220
B	LYS221
B	GLY223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9HJ28","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16154095","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphohistidine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P22253","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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