1VLJ
Crystal structure of NADH-dependent butanol dehydrogenase A (TM0820) from Thermotoga maritima at 1.78 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| A | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| B | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE A 400 |
| Chain | Residue |
| A | ASP195 |
| A | HIS199 |
| A | HIS268 |
| A | HIS282 |
| A | NAP800 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE B 400 |
| Chain | Residue |
| B | NAP800 |
| B | ASP195 |
| B | HIS199 |
| B | HIS268 |
| B | HIS282 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP A 800 |
| Chain | Residue |
| A | GLY40 |
| A | GLY41 |
| A | SER42 |
| A | PRO71 |
| A | PRO73 |
| A | GLY98 |
| A | GLY99 |
| A | SER100 |
| A | ASP103 |
| A | THR139 |
| A | ILE140 |
| A | ALA142 |
| A | THR143 |
| A | THR145 |
| A | ASN148 |
| A | ASN150 |
| A | VAL152 |
| A | LYS161 |
| A | VAL180 |
| A | THR183 |
| A | LEU184 |
| A | GLN188 |
| A | HIS199 |
| A | LEU252 |
| A | HIS282 |
| A | FE400 |
| A | HOH815 |
| A | HOH891 |
| A | HOH894 |
| A | HOH931 |
| A | HOH942 |
| A | HOH960 |
| A | HOH995 |
| A | HOH996 |
| A | HOH1043 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP B 800 |
| Chain | Residue |
| B | GLY40 |
| B | SER42 |
| B | PRO71 |
| B | ASN72 |
| B | PRO73 |
| B | GLY98 |
| B | GLY99 |
| B | SER100 |
| B | ASP103 |
| B | THR139 |
| B | ILE140 |
| B | ALA142 |
| B | THR143 |
| B | THR145 |
| B | ASN148 |
| B | ASN150 |
| B | VAL152 |
| B | LYS161 |
| B | VAL180 |
| B | THR183 |
| B | LEU184 |
| B | GLN188 |
| B | HIS199 |
| B | LEU252 |
| B | HIS282 |
| B | FE400 |
| B | HOH814 |
| B | HOH868 |
| B | HOH871 |
| B | HOH881 |
Functional Information from PROSITE/UniProt
| site_id | PS00060 |
| Number of Residues | 21 |
| Details | ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. WaCHriEHsLSAlydIaHGaG |
| Chain | Residue | Details |
| A | TRP265-GLY285 |
| site_id | PS00913 |
| Number of Residues | 29 |
| Details | ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. SIiDpsvqftlPkeqtVyGavDAIshilE |
| Chain | Residue | Details |
| A | SER174-GLU202 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| A | HIS272 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| B | HIS272 |
