1VL9
Atomic resolution (0.97A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002227 | biological_process | innate immune response in mucosa |
A | 0004623 | molecular_function | phospholipase A2 activity |
A | 0005102 | molecular_function | signaling receptor binding |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0006644 | biological_process | phospholipid metabolic process |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0009986 | cellular_component | cell surface |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019731 | biological_process | antibacterial humoral response |
A | 0032052 | molecular_function | bile acid binding |
A | 0046470 | biological_process | phosphatidylcholine metabolic process |
A | 0046471 | biological_process | phosphatidylglycerol metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
A | 0050482 | biological_process | arachidonic acid secretion |
A | 0050830 | biological_process | defense response to Gram-positive bacterium |
A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
A | 1904635 | biological_process | positive regulation of podocyte apoptotic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 124 |
Chain | Residue |
A | TYR28 |
A | GLY30 |
A | GLY32 |
A | ASP49 |
A | HOH204 |
A | HOH206 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 125 |
Chain | Residue |
A | HOH207 |
A | HOH212 |
A | HOH431 |
A | ASN71 |
A | ASN72 |
A | GLU92 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 126 |
Chain | Residue |
A | LYS12 |
A | GLU81 |
A | ILE82 |
A | ARG100 |
A | ILE104 |
A | HOH264 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MRD A 1603 |
Chain | Residue |
A | MET56 |
A | TYR69 |
A | HOH387 |
A | HOH399 |
A | MPD1602 |
A | MPD1605 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MRD A 1604 |
Chain | Residue |
A | LEU2 |
A | PRO18 |
A | PHE22 |
A | GLY30 |
A | HOH206 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MRD A 1606 |
Chain | Residue |
A | SER15 |
A | TYR111 |
A | HOH438 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE MPD A 1601 |
Chain | Residue |
A | ASN23 |
A | ASN24 |
A | GLY26 |
A | CYS27 |
A | CYS29 |
A | GLY30 |
A | LEU31 |
A | GLY32 |
A | LEU118 |
A | HOH210 |
A | HOH227 |
A | HOH305 |
A | HOH370 |
A | HOH376 |
A | HOH380 |
A | HOH385 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MPD A 1602 |
Chain | Residue |
A | LEU31 |
A | ASP49 |
A | MET56 |
A | TYR69 |
A | HOH204 |
A | MRD1603 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MPD A 1605 |
Chain | Residue |
A | LEU2 |
A | LEU58 |
A | PHE94 |
A | HOH313 |
A | HOH387 |
A | MRD1603 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:7464926 |
Chain | Residue | Details |
A | HIS48 | |
A | ASP99 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS |
Chain | Residue | Details |
A | TYR28 | |
A | GLY30 | |
A | GLY32 | |
A | ASP49 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1n29 |
Chain | Residue | Details |
A | HIS48 | |
A | GLY30 | |
A | ASP99 |