1VKQ

A re-determination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6A resolution using sulphur-SAS at 1.54A wavelength

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002227	biological_process	innate immune response in mucosa
A	0004623	molecular_function	phospholipase A2 activity
A	0005102	molecular_function	signaling receptor binding
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006644	biological_process	phospholipid metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0032052	molecular_function	bile acid binding
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050482	biological_process	arachidonate secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	1904635	biological_process	positive regulation of podocyte apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 224

Chain	Residue
A	TYR28
A	GLY30
A	GLY32
A	ASP49
A	HOH245
A	HOH248

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 225

Chain	Residue
A	HOH332
A	LYS12
A	ILE82
A	ILE104

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 226

Chain	Residue
A	PHE5
A	PHE22
A	GLY30
A	HOH245

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD A 227

Chain	Residue
A	LEU19
A	LYS108

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 228

Chain	Residue
A	SER15
A	ASP21
A	GLN54
A	PHE94
A	HOH265

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Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC

Chain	Residue	Details
A	CYS44-CYS51

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICNCDRNAaIC

Chain	Residue	Details
A	ILE95-CYS105

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"7464926","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10089353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7265241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9115986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BP2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	HIS48
A	GLY30
A	ASP99

---