1VJY

Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 460 A 999

Chain	Residue
A	ALA230
A	LEU340
A	ASP351
A	HOH1001
A	LYS232
A	TYR249
A	LEU260
A	LEU278
A	SER280
A	ASP281
A	TYR282
A	HIS283

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGRFGEVWrGkwrgee............VAVK

Chain	Residue	Details
A	ILE211-LYS232

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV

Chain	Residue	Details
A	ILE329-VAL341

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	92
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	PHE234-LYS326

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site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PRO327-CYS347

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	VAL432
A	ILE411

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	ILE365

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by TGFBR2 => ECO:0000269|PubMed:7774578

Chain	Residue	Details
A	ASP386
A	ASP385

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site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine; by TGFBR2 => ECO:0000269|PubMed:7774578

Chain	Residue	Details
A	ASN389
A	LYS391
A	SER387

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLU245

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