Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1VHW

Crystal structure of purine nucleoside phosphorylase with adenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042278	biological_process	purine nucleoside metabolic process
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0042278	biological_process	purine nucleoside metabolic process
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0042278	biological_process	purine nucleoside metabolic process
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0042278	biological_process	purine nucleoside metabolic process
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0042278	biological_process	purine nucleoside metabolic process
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0042278	biological_process	purine nucleoside metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADN A 252

Chain	Residue
A	MET65
A	GLU182
A	HOH272
A	HOH296
A	HOH379
A	HOH411
D	HIS5
D	ARG44
D	HOH357
A	ARG88
A	SER91
A	CYS92
A	GLY93
A	PHE160
A	VAL179
A	GLU180
A	MET181

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADN B 252

Chain	Residue
B	MET65
B	ARG88
B	SER91
B	CYS92
B	GLY93
B	PHE160
B	VAL179
B	GLU180
B	MET181
B	GLU182
B	HOH286
B	HOH299
B	HOH334
B	HOH347
B	HOH353
B	HOH422
F	HIS5
F	ARG44

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADN C 252

Chain	Residue
C	MET65
C	ARG88
C	SER91
C	CYS92
C	GLY93
C	PHE160
C	VAL179
C	GLU180
C	MET181
C	GLU182
C	HOH289
C	HOH301
C	HOH341
C	HOH360
C	HOH371
E	HIS5
E	ARG44

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADN D 252

Chain	Residue
A	HIS5
A	ARG44
D	MET65
D	ARG88
D	SER91
D	CYS92
D	GLY93
D	PHE160
D	VAL179
D	GLU180
D	MET181
D	GLU182
D	HOH288
D	HOH291
D	HOH342
D	HOH361
D	HOH369

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADN E 252

Chain	Residue
C	HIS5
C	ARG44
C	HOH381
E	MET65
E	ARG88
E	SER91
E	CYS92
E	GLY93
E	PHE160
E	VAL179
E	GLU180
E	MET181
E	GLU182
E	HOH268
E	HOH296
E	HOH366
E	HOH400

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADN F 252

Chain	Residue
F	HOH298
F	HOH331
F	HOH340
F	HOH352
B	HIS5
B	ARG44
F	MET65
F	ARG88
F	SER91
F	CYS92
F	GLY93
F	PHE160
F	VAL179
F	GLU180
F	MET181
F	GLU182
F	HOH284

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIyvtEL

Chain	Residue	Details
A	GLY62-LEU77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ASP205
B	ASP205
C	ASP205
D	ASP205
E	ASP205
F	ASP205

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0007744\|PDB:1VHW

Chain	Residue	Details
A	HIS5
B	HIS5
C	HIS5
D	HIS5
E	HIS5
F	HIS5

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: in other chain => ECO:0007744\|PDB:3OF3

Chain	Residue	Details
A	GLY21
D	GLY21
D	ARG25
D	ARG88
E	GLY21
E	ARG25
E	ARG88
F	GLY21
F	ARG25
F	ARG88
A	ARG25
A	ARG88
B	GLY21
B	ARG25
B	ARG88
C	GLY21
C	ARG25
C	ARG88

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0007744\|PDB:3OF3

Chain	Residue	Details
A	ARG44
B	ARG44
C	ARG44
D	ARG44
E	ARG44
F	ARG44

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: in other chain => ECO:0007744\|PDB:1VHW

Chain	Residue	Details
A	GLU180
B	GLU180
C	GLU180
D	GLU180
E	GLU180
F	GLU180

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: in other chain => ECO:0000250\|UniProtKB:P50389

Chain	Residue	Details
A	SER204
B	SER204
C	SER204
D	SER204
E	SER204
F	SER204

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Important for catalytic activity => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ARG218
B	ARG218
C	ARG218
D	ARG218
E	ARG218
F	ARG218

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
A	ARG218
A	ASP205

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
B	ARG218
B	ASP205

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
C	ARG218
C	ASP205

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
D	ARG218
D	ASP205

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
E	ARG218
E	ASP205

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
F	ARG218
F	ASP205

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)