Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1VHC

Crystal structure of a putative KHG/KDPG aldolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
A	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
A	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
B	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
B	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
B	0016829	molecular_function	lyase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
C	0005737	cellular_component	cytoplasm
C	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
C	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
C	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
C	0016829	molecular_function	lyase activity
C	0016832	molecular_function	aldehyde-lyase activity
C	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
D	0005737	cellular_component	cytoplasm
D	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
D	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
D	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
D	0016829	molecular_function	lyase activity
D	0016832	molecular_function	aldehyde-lyase activity
D	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
E	0005737	cellular_component	cytoplasm
E	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
E	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
E	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
E	0016829	molecular_function	lyase activity
E	0016832	molecular_function	aldehyde-lyase activity
E	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
F	0005737	cellular_component	cytoplasm
F	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
F	0008700	molecular_function	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
F	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
F	0016829	molecular_function	lyase activity
F	0016832	molecular_function	aldehyde-lyase activity
F	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity

Functional Information from PROSITE/UniProt

site_id	PS00159
Number of Residues	10
Details	ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GLsvaEITFR

Chain	Residue	Details
A	GLY40-ARG49

site_id	PS00160
Number of Residues	14
Details	ALDOLASE_KDPG_KHG_2 KDPG and KHG aldolases Schiff-base forming residue. GisaVKFFPAeasG

Chain	Residue	Details
A	GLY128-GLY141

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:P0A955

Chain	Residue	Details
A	GLU45
B	GLU45
C	GLU45
D	GLU45
E	GLU45
F	GLU45

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000250\|UniProtKB:P0A955

Chain	Residue	Details
A	LYS133
B	LYS133
C	LYS133
D	LYS133
E	LYS133
F	LYS133

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P0A955

Chain	Residue	Details
A	ARG49
E	THR73
F	ARG49
F	THR73
A	THR73
B	ARG49
B	THR73
C	ARG49
C	THR73
D	ARG49
D	THR73
E	ARG49

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: covalent => ECO:0000250\|UniProtKB:P0A955

Chain	Residue	Details
A	LYS133
B	LYS133
C	LYS133
D	LYS133
E	LYS133
F	LYS133

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Plays a major role in determining the stereoselectivity => ECO:0000250\|UniProtKB:P0A955

Chain	Residue	Details
A	THR161
B	THR161
C	THR161
D	THR161
E	THR161
F	THR161

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
A	LYS133
A	GLU45

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
B	LYS133
B	GLU45

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
C	LYS133
C	GLU45

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
D	LYS133
D	GLU45

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
E	LYS133
E	GLU45

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1fq0

Chain	Residue	Details
F	LYS133
F	GLU45

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)