1VHC
Crystal structure of a putative KHG/KDPG aldolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016832 | molecular_function | aldehyde-lyase activity |
| C | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016832 | molecular_function | aldehyde-lyase activity |
| D | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016832 | molecular_function | aldehyde-lyase activity |
| E | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016832 | molecular_function | aldehyde-lyase activity |
| F | 0106009 | molecular_function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P0A955","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"UniProtKB","id":"P0A955","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A955","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"UniProtKB","id":"P0A955","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Plays a major role in determining the stereoselectivity","evidences":[{"source":"UniProtKB","id":"P0A955","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| A | LYS133 | |
| A | GLU45 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| B | LYS133 | |
| B | GLU45 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| C | LYS133 | |
| C | GLU45 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| D | LYS133 | |
| D | GLU45 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| E | LYS133 | |
| E | GLU45 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fq0 |
| Chain | Residue | Details |
| F | LYS133 | |
| F | GLU45 |
