Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 163 |
| Chain | Residue |
| B | ARG46 |
| B | SER65 |
| B | ARG66 |
| B | ARG69 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 163 |
| Chain | Residue |
| A | HOH173 |
| A | ARG46 |
| A | SER65 |
| A | ARG66 |
| A | SER67 |
| A | ARG69 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 164 |
| Chain | Residue |
| A | GLY45 |
| A | ARG46 |
| A | THR47 |
| A | THR48 |
| A | GLY101 |
| A | GLY102 |
| A | ILE105 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrdgeLPWpsipaDkkqYrsrI |
| Chain | Residue | Details |
| A | VAL14-ILE37 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA8 | |
| B | THR47 | |
| B | SER67 | |
| B | GLY101 | |
| A | VAL14 | |
| A | ASP29 | |
| A | THR47 | |
| A | SER67 | |
| A | GLY101 | |
| B | ALA8 | |
| B | VAL14 | |
| B | ASP29 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | LEU21 | |
| A | ASP29 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| B | LEU21 | |
| B | ASP29 | |
