1VDN
Crystal Structure Of Yeast Cyclophilin A Complexed With ACE-Ala-Ala-Pro-Ala-7-Amino-4-Methylcoumarin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0006457 | biological_process | protein folding |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009267 | biological_process | cellular response to starvation |
| A | 0015031 | biological_process | protein transport |
| A | 0016018 | molecular_function | cyclosporin A binding |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030437 | biological_process | ascospore formation |
| A | 0034967 | cellular_component | Set3 complex |
| A | 0045835 | biological_process | negative regulation of meiotic nuclear division |
| A | 0045836 | biological_process | positive regulation of meiotic nuclear division |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR CHAIN B OF (ACE)AAPA(MCM) |
| Chain | Residue |
| A | GLN3 |
| A | ALA99 |
| A | ASN100 |
| A | PHE111 |
| A | PRO116 |
| A | LEU120 |
| A | HIS124 |
| A | PRO146 |
| A | HOH174 |
| A | HOH175 |
| A | HOH186 |
| A | VAL19 |
| A | HOH274 |
| B | HOH54 |
| B | HOH70 |
| B | HOH118 |
| A | ARG53 |
| A | ILE55 |
| A | ASP57 |
| A | PHE58 |
| A | GLN61 |
| A | ASP91 |
| A | ARG92 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YagSpFHRVIpdFMlQGG |
| Chain | Residue | Details |
| A | TYR46-GLY63 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"2687115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8431466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
