1VCO
Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003883 | molecular_function | CTP synthase activity |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097268 | cellular_component | cytoophidium |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLN A 610 |
| Chain | Residue |
| A | TYR64 |
| A | ARG472 |
| A | TYR473 |
| A | HOH753 |
| A | GLY363 |
| A | GLY364 |
| A | PHE365 |
| A | CYS391 |
| A | LEU392 |
| A | GLN395 |
| A | GLU415 |
| A | HIS471 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000305|PubMed:15296735 |
| Chain | Residue | Details |
| A | CYS391 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000305|PubMed:15296735 |
| Chain | Residue | Details |
| A | HIS522 | |
| A | GLU524 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01227 |
| Chain | Residue | Details |
| A | SER23 | |
| A | SER24 | |
| A | ASP81 | |
| A | GLU151 | |
| A | ASP158 | |
| A | LYS198 | |
| A | LYS234 | |
| A | VAL252 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15296735, ECO:0007744|PDB:1VCO |
| Chain | Residue | Details |
| A | TYR64 | |
| A | GLY364 | |
| A | LEU392 | |
| A | GLU415 | |
| A | ARG472 |
