1V9A
Crystal structure of Uroporphyrin-III C-methyl transferase from Thermus thermophilus complexed with S-adenyl homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004851 | molecular_function | uroporphyrin-III C-methyltransferase activity |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019354 | biological_process | siroheme biosynthetic process |
| A | 0032259 | biological_process | methylation |
| B | 0004851 | molecular_function | uroporphyrin-III C-methyltransferase activity |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019354 | biological_process | siroheme biosynthetic process |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FLC A 601 |
| Chain | Residue |
| A | ARG35 |
| A | VAL138 |
| A | MET160 |
| A | GLY161 |
| A | VAL162 |
| A | GLY163 |
| A | HOH605 |
| A | HOH650 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE FLC B 602 |
| Chain | Residue |
| B | VAL138 |
| B | MET160 |
| B | GLY161 |
| B | VAL162 |
| B | GLY163 |
| B | HOH611 |
| B | HOH614 |
| B | HOH647 |
| B | HOH660 |
| B | ARG35 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 501 |
| Chain | Residue |
| A | PRO11 |
| A | GLY84 |
| A | GLY85 |
| A | ASP86 |
| A | VAL89 |
| A | PHE90 |
| A | THR114 |
| A | SER115 |
| A | LEU159 |
| A | MET160 |
| A | VAL186 |
| A | ARG188 |
| A | ALA189 |
| A | PRO214 |
| A | ALA215 |
| A | LEU216 |
| A | HOH605 |
| A | HOH610 |
| A | HOH616 |
| A | HOH650 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH B 502 |
| Chain | Residue |
| B | PRO11 |
| B | GLY84 |
| B | ASP86 |
| B | VAL89 |
| B | PHE90 |
| B | THR114 |
| B | SER115 |
| B | LEU159 |
| B | MET160 |
| B | VAL186 |
| B | ARG188 |
| B | ALA189 |
| B | PRO214 |
| B | ALA215 |
| B | LEU216 |
| B | HOH611 |
| B | HOH619 |
| B | HOH620 |
| B | HOH647 |
Functional Information from PROSITE/UniProt
| site_id | PS00839 |
| Number of Residues | 15 |
| Details | SUMT_1 Uroporphyrin-III C-methyltransferase signature 1. VGAGPGdpeLLTLKA |
| Chain | Residue | Details |
| A | VAL7-ALA21 |
| site_id | PS00840 |
| Number of Residues | 34 |
| Details | SUMT_2 Uroporphyrin-III C-methyltransferase signature 2. VvrLkgGDpmvFGrggeevlfLlrhgvpVeVvPG |
| Chain | Residue | Details |
| A | VAL79-GLY112 |
