Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004489 | molecular_function | methylenetetrahydrofolate reductase [NAD(P)H] activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006555 | biological_process | methionine metabolic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0071949 | molecular_function | FAD binding |
| A | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE FAD A 300 |
| Chain | Residue |
| A | THR49 |
| A | TYR126 |
| A | ALA127 |
| A | ALA147 |
| A | TYR149 |
| A | HIS153 |
| A | GLU155 |
| A | SER156 |
| A | HIS165 |
| A | LYS169 |
| A | ILE178 |
| A | TYR50 |
| A | GLN180 |
| A | PRO243 |
| A | TYR272 |
| A | HOH501 |
| A | HOH521 |
| A | HOH523 |
| A | HOH528 |
| A | HOH545 |
| A | HOH671 |
| A | HIS77 |
| A | THR79 |
| A | LEU104 |
| A | LEU106 |
| A | ARG107 |
| A | GLY108 |
| A | ASP109 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DIO A 301 |
| Chain | Residue |
| A | PRO13 |
| A | LEU14 |
| A | VAL269 |
| A | PHE271 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DIO A 302 |
| Chain | Residue |
| A | GLY82 |
| A | PRO111 |
| A | ARG118 |
| A | PRO119 |
| A | HIS120 |
| A | PRO121 |
| A | ARG290 |
| A | HOH674 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DIO A 303 |
| Chain | Residue |
| A | ALA62 |
| A | TRP63 |
| A | ARG66 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DIO A 304 |
| Chain | Residue |
| A | ARG164 |
| A | ALA198 |
| A | ASP241 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DIO A 305 |
| Chain | Residue |
| A | LYS235 |
| A | HIS239 |
| A | ALA245 |
| A | GLU248 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DIO A 306 |
| Chain | Residue |
| A | ARG219 |
| A | LEU262 |
| A | GLU263 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b5t |
| Chain | Residue | Details |
| A | ASP109 | |
| A | GLU18 | |
