1V8F

Crystal Structure of Pantoate-beta-Alanine (Pantothenate Synthetase) from Thermus Thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004592	molecular_function	pantoate-beta-alanine ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009058	biological_process	biosynthetic process
A	0015940	biological_process	pantothenate biosynthetic process
A	0016874	molecular_function	ligase activity
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004592	molecular_function	pantoate-beta-alanine ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009058	biological_process	biosynthetic process
B	0015940	biological_process	pantothenate biosynthetic process
B	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1301

Chain	Residue
A	MET25
A	GLN56
A	ARG117
A	HIS120
A	ARG183

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 1302

Chain	Residue
B	ARG183
B	HOH1613
B	MET25
B	GLN56
B	ARG117
B	HIS120

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1303

Chain	Residue
A	GLY58
A	PRO59
A	GLY60

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1304

Chain	Residue
B	MET25
B	HIS32

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1305

Chain	Residue
A	MET25
A	HIS32
A	1441501
A	HOH1966

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 144 A 1501

Chain	Residue
A	MET25
A	GLN56
A	VAL127
A	GLN149
A	CL1305
A	HOH1602
A	HOH1752
A	HOH1966

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE P6G A 1601

Chain	Residue
A	ARG2
A	VAL4
A	ALA13
A	PHE45
A	LYS194
A	GLU231
A	ARG233
A	HOH1873
A	HOH1888

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1401

Chain	Residue
B	PRO23
B	GLN56
B	VAL127
B	GLN149
B	HOH1441

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1402

Chain	Residue
A	GLU61
A	ASP62
A	ARG183
A	ARG262
A	ARG267
A	HOH1608
A	HOH1824

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 1403

Chain	Residue
A	SER214

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1404

Chain	Residue
A	THR109
A	GLY114
A	GLY119
A	HOH1604
A	HOH1610
A	HOH1666
B	GLU105

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1405

Chain	Residue
A	THR6
A	GLU92
A	HOH1745
A	HOH1934
A	HOH2036

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1406

Chain	Residue
A	ALA99
A	ARG101
A	ALA115
A	PRO118
A	HOH1666
A	HOH1846
B	GLU105
B	GLY106

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1407

Chain	Residue
A	HOH1733
B	HIS241
B	THR244
B	VAL252
B	HOH1497

---

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1408

Chain	Residue
A	GLY31
A	HIS32
A	LEU35
A	PRO170
A	THR171
A	VAL172
A	HOH1699
A	HOH1707
A	HOH1830
A	HOH1871

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00158","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00158","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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