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1V5B

The Structure Of The Mutant, S225A and E251L, Of 3-Isopropylmalate Dehydrogenase From Bacillus Coagulans

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003862molecular_function3-isopropylmalate dehydrogenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008652biological_processamino acid biosynthetic process
A0009082biological_processbranched-chain amino acid biosynthetic process
A0009098biological_processL-leucine biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
B0000287molecular_functionmagnesium ion binding
B0003862molecular_function3-isopropylmalate dehydrogenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008652biological_processamino acid biosynthetic process
B0009082biological_processbranched-chain amino acid biosynthetic process
B0009098biological_processL-leucine biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0046872molecular_functionmetal ion binding
B0051287molecular_functionNAD binding
C0000287molecular_functionmagnesium ion binding
C0003862molecular_function3-isopropylmalate dehydrogenase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0008652biological_processamino acid biosynthetic process
C0009082biological_processbranched-chain amino acid biosynthetic process
C0009098biological_processL-leucine biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0046872molecular_functionmetal ion binding
C0051287molecular_functionNAD binding
D0000287molecular_functionmagnesium ion binding
D0003862molecular_function3-isopropylmalate dehydrogenase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008652biological_processamino acid biosynthetic process
D0009082biological_processbranched-chain amino acid biosynthetic process
D0009098biological_processL-leucine biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0046872molecular_functionmetal ion binding
D0051287molecular_functionNAD binding
E0000287molecular_functionmagnesium ion binding
E0003862molecular_function3-isopropylmalate dehydrogenase activity
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0008652biological_processamino acid biosynthetic process
E0009082biological_processbranched-chain amino acid biosynthetic process
E0009098biological_processL-leucine biosynthetic process
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0046872molecular_functionmetal ion binding
E0051287molecular_functionNAD binding
F0000287molecular_functionmagnesium ion binding
F0003862molecular_function3-isopropylmalate dehydrogenase activity
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0008652biological_processamino acid biosynthetic process
F0009082biological_processbranched-chain amino acid biosynthetic process
F0009098biological_processL-leucine biosynthetic process
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0046872molecular_functionmetal ion binding
F0051287molecular_functionNAD binding
G0000287molecular_functionmagnesium ion binding
G0003862molecular_function3-isopropylmalate dehydrogenase activity
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0008652biological_processamino acid biosynthetic process
G0009082biological_processbranched-chain amino acid biosynthetic process
G0009098biological_processL-leucine biosynthetic process
G0016491molecular_functionoxidoreductase activity
G0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G0046872molecular_functionmetal ion binding
G0051287molecular_functionNAD binding
H0000287molecular_functionmagnesium ion binding
H0003862molecular_function3-isopropylmalate dehydrogenase activity
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0008652biological_processamino acid biosynthetic process
H0009082biological_processbranched-chain amino acid biosynthetic process
H0009098biological_processL-leucine biosynthetic process
H0016491molecular_functionoxidoreductase activity
H0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H0046872molecular_functionmetal ion binding
H0051287molecular_functionNAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 H 1001
ChainResidue
ELYS121
FLYS121
FARG122
HLYS319

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 H 1002
ChainResidue
FLYS319
GLYS121
HLYS121
HARG122

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 H 1003
ChainResidue
HARG134
HARG96

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 1004
ChainResidue
BLYS319
CLYS121
CARG122
DLYS121

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1005
ChainResidue
AARG350
GARG144

Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NMFGDIlSDlaSvit.GSLGM
ChainResidueDetails
AASN242-MET261

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues248
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues16
DetailsSite: {"description":"Important for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
AASP222
ALYS190
BTYR141

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
ATYR141
BASP222
BLYS190

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
DTYR141
CASP222
CLYS190

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
CTYR141
DASP222
DLYS190

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
FTYR141
EASP222
ELYS190

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
FASP222
FLYS190
ETYR141

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
HTYR141
GASP222
GLYS190

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a05
ChainResidueDetails
HASP222
HLYS190
GTYR141

239492

PDB entries from 2025-07-30

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