1V3A

Structure of human PRL-3, the phosphatase associated with cancer metastasis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006470	biological_process	protein dephosphorylation
A	0007219	biological_process	Notch signaling pathway
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0043117	biological_process	positive regulation of vascular permeability
A	0043542	biological_process	endothelial cell migration
A	1900746	biological_process	regulation of vascular endothelial growth factor signaling pathway
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1904951	biological_process	positive regulation of establishment of protein localization
A	1990830	biological_process	cellular response to leukemia inhibitory factor

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	153
Details	Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d5r