1UZM
MabA from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| A | 0046459 | biological_process | short-chain fatty acid metabolic process |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| B | 0046459 | biological_process | short-chain fatty acid metabolic process |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0071768 | biological_process | mycolic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 1246 |
| Chain | Residue |
| A | PHE13 |
| A | ALA37 |
| A | ASP38 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 1247 |
| Chain | Residue |
| A | ALA36 |
| A | ALA36 |
| A | HIS40 |
| A | HIS40 |
| A | HOH2052 |
| A | HOH2052 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B 1246 |
| Chain | Residue |
| B | ALA36 |
| B | ALA36 |
| B | HIS40 |
| B | HOH2032 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B 1247 |
| Chain | Residue |
| B | PHE13 |
| B | ALA37 |
| B | ASP38 |
| B | HOH2031 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvsglwgignQanYAASKAGViGMArSIA |
| Chain | Residue | Details |
| A | SER140-ALA168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
| Chain | Residue | Details |
| A | TYR153 | |
| B | TYR153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15977159, ECO:0007744|PDB:1UZN |
| Chain | Residue | Details |
| A | ARG25 | |
| A | ARG47 | |
| A | ASP61 | |
| A | GLY90 | |
| B | ARG25 | |
| B | ARG47 | |
| B | ASP61 | |
| B | GLY90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P71534 |
| Chain | Residue | Details |
| A | TYR153 | |
| A | LYS157 | |
| A | ILE186 | |
| A | ARG197 | |
| B | TYR153 | |
| B | LYS157 | |
| B | ILE186 | |
| B | ARG197 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for activity => ECO:0000305|PubMed:23006410 |
| Chain | Residue | Details |
| A | SER140 | |
| B | SER140 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20178986 |
| Chain | Residue | Details |
| A | THR21 | |
| A | THR114 | |
| A | THR191 | |
| B | THR21 | |
| B | THR114 | |
| B | THR191 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER140 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER140 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER140 | |
| A | ASN112 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER140 | |
| B | ASN112 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | GLN150 | |
| A | LYS157 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | GLN150 | |
| B | LYS157 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | LYS157 | |
| B | TYR153 |
