1UWL
1.76A Structure of Urocanate Hydratase from Pseudomonas putida
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006547 | biological_process | L-histidine metabolic process |
| A | 0006548 | biological_process | L-histidine catabolic process |
| A | 0016153 | molecular_function | urocanate hydratase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019556 | biological_process | L-histidine catabolic process to glutamate and formamide |
| A | 0019557 | biological_process | L-histidine catabolic process to glutamate and formate |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006547 | biological_process | L-histidine metabolic process |
| B | 0006548 | biological_process | L-histidine catabolic process |
| B | 0016153 | molecular_function | urocanate hydratase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019556 | biological_process | L-histidine catabolic process to glutamate and formamide |
| B | 0019557 | biological_process | L-histidine catabolic process to glutamate and formate |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAD A 1555 |
| Chain | Residue |
| A | GLU44 |
| A | GLY179 |
| A | ILE196 |
| A | GLU197 |
| A | SER198 |
| A | GLN199 |
| A | ARG202 |
| A | GLY242 |
| A | ASN243 |
| A | ALA244 |
| A | GLN264 |
| A | TYR52 |
| A | THR265 |
| A | SER266 |
| A | HIS268 |
| A | GLY273 |
| A | TYR274 |
| A | LEU275 |
| A | TYR323 |
| A | ASN325 |
| A | PHE345 |
| A | LEU445 |
| A | GLY53 |
| A | ARG455 |
| A | GLY493 |
| A | HOH2043 |
| A | HOH2441 |
| A | HOH2442 |
| A | HOH2443 |
| A | GLY54 |
| A | GLN131 |
| A | ILE145 |
| A | GLY176 |
| A | GLY177 |
| A | MET178 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAD B 1555 |
| Chain | Residue |
| B | GLU44 |
| B | TYR52 |
| B | GLY53 |
| B | GLY54 |
| B | GLN131 |
| B | ILE145 |
| B | GLY176 |
| B | GLY177 |
| B | MET178 |
| B | GLY179 |
| B | GLU197 |
| B | SER198 |
| B | GLN199 |
| B | ARG202 |
| B | GLY242 |
| B | ASN243 |
| B | ALA244 |
| B | GLN264 |
| B | THR265 |
| B | SER266 |
| B | HIS268 |
| B | GLY273 |
| B | TYR274 |
| B | LEU275 |
| B | TYR323 |
| B | ASN325 |
| B | PHE345 |
| B | LEU445 |
| B | ARG455 |
| B | GLY493 |
| B | HOH2042 |
| B | HOH2337 |
| B | HOH2404 |
| B | HOH2405 |
| B | HOH2406 |
Functional Information from PROSITE/UniProt
| site_id | PS01233 |
| Number of Residues | 16 |
| Details | UROCANASE Urocanase signature. RDHlDsGSvsSPnRET |
| Chain | Residue | Details |
| A | ARG442-THR457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00577, ECO:0000305|PubMed:7901006 |
| Chain | Residue | Details |
| A | TRP412 | |
| B | TRP412 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00577, ECO:0000269|PubMed:15313616, ECO:0000269|PubMed:18187656, ECO:0007744|PDB:1UWK, ECO:0007744|PDB:1UWL, ECO:0007744|PDB:1W1U, ECO:0007744|PDB:2V7G |
| Chain | Residue | Details |
| A | GLY54 | |
| B | MET178 | |
| B | ALA244 | |
| B | THR265 | |
| B | LEU275 | |
| B | VAL494 | |
| A | MET132 | |
| A | MET178 | |
| A | ALA244 | |
| A | THR265 | |
| A | LEU275 | |
| A | VAL494 | |
| B | GLY54 | |
| B | MET132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15313616, ECO:0000269|PubMed:18187656, ECO:0007744|PDB:1UWK, ECO:0007744|PDB:1UWL, ECO:0007744|PDB:1W1U, ECO:0007744|PDB:2V7G |
| Chain | Residue | Details |
| A | SER198 | |
| B | SER198 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15313616, ECO:0000269|PubMed:18187656, ECO:0007744|PDB:1UWK, ECO:0007744|PDB:1UWL, ECO:0007744|PDB:2V7G |
| Chain | Residue | Details |
| A | GLY324 | |
| B | GLY324 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15313616, ECO:0000269|PubMed:18187656, ECO:0007744|PDB:1W1U, ECO:0007744|PDB:2V7G |
| Chain | Residue | Details |
| A | GLU456 | |
| B | GLU456 |
