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1UW5

Structure of PITP-alpha complexed to phosphatidylinositol

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005548molecular_functionphospholipid transporter activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006869biological_processlipid transport
A0007409biological_processaxonogenesis
A0007601biological_processvisual perception
A0008289molecular_functionlipid binding
A0008525molecular_functionphosphatidylcholine transporter activity
A0008526molecular_functionphosphatidylinositol transfer activity
A0015914biological_processphospholipid transport
A0031210molecular_functionphosphatidylcholine binding
A0035091molecular_functionphosphatidylinositol binding
A0070062cellular_componentextracellular exosome
A0120009biological_processintermembrane lipid transfer
A0120019molecular_functionphosphatidylcholine transfer activity
A1901611molecular_functionphosphatidylglycerol binding
B0005515molecular_functionprotein binding
B0005548molecular_functionphospholipid transporter activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006869biological_processlipid transport
B0007409biological_processaxonogenesis
B0007601biological_processvisual perception
B0008289molecular_functionlipid binding
B0008525molecular_functionphosphatidylcholine transporter activity
B0008526molecular_functionphosphatidylinositol transfer activity
B0015914biological_processphospholipid transport
B0031210molecular_functionphosphatidylcholine binding
B0035091molecular_functionphosphatidylinositol binding
B0070062cellular_componentextracellular exosome
B0120009biological_processintermembrane lipid transfer
B0120019molecular_functionphosphatidylcholine transfer activity
B1901611molecular_functionphosphatidylglycerol binding
C0005515molecular_functionprotein binding
C0005548molecular_functionphospholipid transporter activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006869biological_processlipid transport
C0007409biological_processaxonogenesis
C0007601biological_processvisual perception
C0008289molecular_functionlipid binding
C0008525molecular_functionphosphatidylcholine transporter activity
C0008526molecular_functionphosphatidylinositol transfer activity
C0015914biological_processphospholipid transport
C0031210molecular_functionphosphatidylcholine binding
C0035091molecular_functionphosphatidylinositol binding
C0070062cellular_componentextracellular exosome
C0120009biological_processintermembrane lipid transfer
C0120019molecular_functionphosphatidylcholine transfer activity
C1901611molecular_functionphosphatidylglycerol binding
D0005515molecular_functionprotein binding
D0005548molecular_functionphospholipid transporter activity
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006869biological_processlipid transport
D0007409biological_processaxonogenesis
D0007601biological_processvisual perception
D0008289molecular_functionlipid binding
D0008525molecular_functionphosphatidylcholine transporter activity
D0008526molecular_functionphosphatidylinositol transfer activity
D0015914biological_processphospholipid transport
D0031210molecular_functionphosphatidylcholine binding
D0035091molecular_functionphosphatidylinositol binding
D0070062cellular_componentextracellular exosome
D0120009biological_processintermembrane lipid transfer
D0120019molecular_functionphosphatidylcholine transfer activity
D1901611molecular_functionphosphatidylglycerol binding
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PIE A1270
ChainResidue
AGLN22
ATHR96
AILE98
AILE111
ALYS194
AGLU217
ALEU220
APHE224
AVAL26
ATHR58
ALYS60
ATYR62
AILE83
AGLU85
AASN89
ACYS94

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PIE B1270
ChainResidue
BGLN22
BVAL26
BGLU33
BTHR58
BLYS60
BTYR62
BGLU85
BASN89
BCYS94
BTHR96
BILE98
BLYS194
BGLU217
BLEU220
BPHE224

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PIE C1270
ChainResidue
CGLN22
CTHR58
CLYS60
CILE83
CGLU85
CASN89
CCYS94
CTHR96
CILE98
CILE111
CLYS194
CGLU217
CLEU220
CPHE224

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PIE D1270
ChainResidue
DGLU33
DTHR58
DLYS60
DTYR62
DGLU85
DASN89
DCYS94
DTHR96
DILE111
DLYS194
DGLU217
DLEU220
DPHE221
DPHE224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:14962392
ChainResidueDetails
AHIS59
AILE61
ALYS86
AALA90
AVAL97
ALEU195
BHIS59
BILE61
BLYS86
BALA90
BVAL97
BLEU195
CHIS59
CILE61
CLYS86
CALA90
CVAL97
CLEU195
DHIS59
DILE61
DLYS86
DALA90
DVAL97
DLEU195

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
AGLN216
BGLN216
CGLN216
DGLN216

219140

PDB entries from 2024-05-01

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