1UTN

Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 248

Chain	Residue
A	ASN95
A	THR98
A	ASN100
A	HOH2272
A	HOH2273
A	HOH2274
A	HOH2275

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 249

Chain	Residue
A	GLY193
A	SER195
A	ABN246
A	HOH2277
A	HIS57
A	GLN192

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 250

Chain	Residue
A	LYS145
A	SER146
A	SER147
A	HOH2278

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 251

Chain	Residue
A	LYS169
A	PRO173
A	GLY174
A	HOH2207
A	HOH2281

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 252

Chain	Residue
A	PRO124
A	THR125
A	SER127
A	SER146
A	SER147
A	GLY148
A	LYS204
A	HOH2228
A	HOH2229
A	HOH2282

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A6000

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU80
A	HOH2070
A	HOH2085

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ABN A 246

Chain	Residue
A	ASP189
A	SER190
A	CYS191
A	GLN192
A	SER195
A	VAL213
A	TRP215
A	GLY219
A	CYS220
A	SO4249
A	HOH2271

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ABN A 247

Chain	Residue
A	ALA24
A	ASN25
A	SER116
A	ARG117
A	PRO173
A	GLY174

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRS A 256

Chain	Residue
A	ASN34
A	GLY38
A	TYR39
A	HIS40
A	ILE73
A	ASN74
A	ILE89
A	VAL90
A	PRO92
A	HOH2104

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 253

Chain	Residue
A	GLU80
A	GLN81
A	PHE82

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 254

Chain	Residue
A	CYS128
A	ALA129
A	PHE181
A	GLN210
A	LYS230
A	HOH2191
A	HOH2233
A	HOH2286

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	GLY193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	GLY193
A	HIS57

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57
A	GLY196

---