1URK

SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR

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Functional Information from GO Data

ChainGOidnamespacecontents
A0009986cellular_componentcell surface
A0070062cellular_componentextracellular exosome
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005925cellular_componentfocal adhesion
A0005886cellular_componentplasma membrane
A0035579cellular_componentspecific granule membrane
A0070821cellular_componenttertiary granule membrane
A0004252molecular_functionserine-type endopeptidase activity
A0007596biological_processblood coagulation
A0006935biological_processchemotaxis
A0042730biological_processfibrinolysis
A0043312biological_processneutrophil degranulation
A0031639biological_processplasminogen activation
A0030335biological_processpositive regulation of cell migration
A0006508biological_processproteolysis
A0033628biological_processregulation of cell adhesion mediated by integrin
A0042127biological_processregulation of cell proliferation
A0010469biological_processregulation of signaling receptor activity
A0014910biological_processregulation of smooth muscle cell migration
A2000097biological_processregulation of smooth muscle cell-matrix adhesion
A0061041biological_processregulation of wound healing
A0001666biological_processresponse to hypoxia
A0007165biological_processsignal transduction
A0014909biological_processsmooth muscle cell migration
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC13BINDING SITE FOR RESIDUE FUC A 136
ChainResidue
AGLY16
AGLY17
ATHR18

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
FUC_1urk_A_136112ALPHA-L-FUCOSE binding site
ChainResidueligand
AGLN6-CYS11FUC: ALPHA-L-FUCOSE
AGLY16-CYS19FUC: ALPHA-L-FUCOSE
AASN22-ILE28FUC: ALPHA-L-FUCOSE
AASN32-PRO34FUC: ALPHA-L-FUCOSE
ATHR83-TYR84FUC: ALPHA-L-FUCOSE
AARG88-ASP90FUC: ALPHA-L-FUCOSE
ALEU92-LEU94FUC: ALPHA-L-FUCOSE
AASN104-ARG108FUC: ALPHA-L-FUCOSE
AARG110FUC: ALPHA-L-FUCOSE
ATRP112FUC: ALPHA-L-FUCOSE
AGLU125FUC: ALPHA-L-FUCOSE
ALYS135FUC: ALPHA-L-FUCOSE
AASP12FUC: ALPHA-L-FUCOSE
ALEU14-ASN15FUC: ALPHA-L-FUCOSE
AGLY39-ILE44FUC: ALPHA-L-FUCOSE
AGLN116-LYS120FUC: ALPHA-L-FUCOSE
ALYS35-GLY38FUC: ALPHA-L-FUCOSE
AASP45-CYS50FUC: ALPHA-L-FUCOSE
ATYR58FUC: ALPHA-L-FUCOSE
AALA62-THR66FUC: ALPHA-L-FUCOSE
ACYS71FUC: ALPHA-L-FUCOSE
ATYR101-ARG103FUC: ALPHA-L-FUCOSE
APRO111FUC: ALPHA-L-FUCOSE
ACYS113-TYR114FUC: ALPHA-L-FUCOSE
ALEU122FUC: ALPHA-L-FUCOSE
AGLN124FUC: ALPHA-L-FUCOSE
ACYS126-GLY134FUC: ALPHA-L-FUCOSE
ATRP30FUC: ALPHA-L-FUCOSE
APHE57FUC: ALPHA-L-FUCOSE
AARG59-GLY60FUC: ALPHA-L-FUCOSE
ACYS13FUC: ALPHA-L-FUCOSE
AVAL20-SER21FUC: ALPHA-L-FUCOSE
AHIS29FUC: ALPHA-L-FUCOSE
ACYS31FUC: ALPHA-L-FUCOSE
AASN54FUC: ALPHA-L-FUCOSE
AHIS56FUC: ALPHA-L-FUCOSE
ALYS61FUC: ALPHA-L-FUCOSE
ATRP74FUC: ALPHA-L-FUCOSE
AALA91FUC: ALPHA-L-FUCOSE
AGLY95-ASN100FUC: ALPHA-L-FUCOSE
ATYR51-GLU52FUC: ALPHA-L-FUCOSE
AGLY55FUC: ALPHA-L-FUCOSE
AMET67FUC: ALPHA-L-FUCOSE
AARG69FUC: ALPHA-L-FUCOSE
AARG109FUC: ALPHA-L-FUCOSE
AVAL123FUC: ALPHA-L-FUCOSE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0002212EGF-like domain signature 1. C-x-C-x(2)-{V}-x(2)-G-{C}-x-C
ChainResidueDetails
ACYS31-CYS42

PS0002113Kringle domain signature. [FY]-C-[RH]-[NS]-x(7,8)-[WY]-C
ChainResidueDetails
ATYR101-CYS113

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13Charge relay system.
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI22Cleavage; during zymogen activation.
ChainResidueDetails
ANA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails