1UQR
Type II 3-dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019631 | biological_process | quinate catabolic process |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019631 | biological_process | quinate catabolic process |
| C | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019631 | biological_process | quinate catabolic process |
| D | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019631 | biological_process | quinate catabolic process |
| E | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019631 | biological_process | quinate catabolic process |
| F | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019631 | biological_process | quinate catabolic process |
| G | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019631 | biological_process | quinate catabolic process |
| H | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0019631 | biological_process | quinate catabolic process |
| I | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| I | 0009423 | biological_process | chorismate biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0019631 | biological_process | quinate catabolic process |
| J | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| J | 0009423 | biological_process | chorismate biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0019631 | biological_process | quinate catabolic process |
| K | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| K | 0009423 | biological_process | chorismate biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0019631 | biological_process | quinate catabolic process |
| L | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| L | 0009423 | biological_process | chorismate biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0019631 | biological_process | quinate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SO4 A1147 |
| Chain | Residue |
| A | GLY53 |
| B | HOH2098 |
| B | HOH2103 |
| C | GLY53 |
| C | GLU54 |
| C | GLU55 |
| C | HOH2102 |
| C | HOH2104 |
| A | GLU54 |
| A | GLU55 |
| A | HOH2098 |
| A | HOH2191 |
| A | HOH2192 |
| B | GLY53 |
| B | GLU54 |
| B | GLU55 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A1148 |
| Chain | Residue |
| A | ASN74 |
| A | LEU101 |
| A | SER102 |
| A | HOH2136 |
| A | HOH2193 |
| A | HOH2194 |
| A | HOH2195 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B1147 |
| Chain | Residue |
| B | ASN74 |
| B | HIS100 |
| B | LEU101 |
| B | SER102 |
| B | HOH2155 |
| B | HOH2156 |
| B | HOH2199 |
| B | HOH2200 |
| B | HOH2202 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1148 |
| Chain | Residue |
| B | LYS17 |
| B | THR27 |
| B | SER29 |
| B | HOH2203 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C1154 |
| Chain | Residue |
| C | ASN74 |
| C | HIS100 |
| C | LEU101 |
| C | SER102 |
| C | HOH2208 |
| C | HOH2209 |
| C | HOH2210 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C1155 |
| Chain | Residue |
| C | LYS17 |
| C | THR27 |
| C | SER29 |
| C | HOH2211 |
| C | HOH2212 |
| C | HOH2213 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C1156 |
| Chain | Residue |
| C | LEU15 |
| C | GLY16 |
| C | LYS17 |
| C | ARG18 |
| C | HOH2215 |
| C | HOH2216 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D1152 |
| Chain | Residue |
| D | ASN74 |
| D | HIS100 |
| D | LEU101 |
| D | SER102 |
| D | HOH2031 |
| D | HOH2201 |
| D | HOH2202 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D1153 |
| Chain | Residue |
| D | LYS17 |
| D | THR27 |
| D | SER29 |
| D | HOH2042 |
| D | HOH2203 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D1154 |
| Chain | Residue |
| D | LEU15 |
| D | GLY16 |
| D | LYS17 |
| D | ARG18 |
| D | HIS21 |
| D | ILE22 |
| D | TYR23 |
| D | GLY24 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E1147 |
| Chain | Residue |
| E | ASN74 |
| E | HIS100 |
| E | LEU101 |
| E | SER102 |
| E | HOH2025 |
| E | HOH2119 |
| E | HOH2160 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E1148 |
| Chain | Residue |
| E | LYS17 |
| E | THR27 |
| E | HOH2161 |
| E | HOH2162 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E1149 |
| Chain | Residue |
| E | LEU15 |
| E | GLY16 |
| E | LYS17 |
| E | ARG18 |
| E | ILE22 |
| E | TYR23 |
| E | GLY24 |
| E | HOH2026 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SO4 F1152 |
| Chain | Residue |
| D | HOH2107 |
| E | GLY53 |
| E | GLU54 |
| E | GLU55 |
| F | GLY53 |
| F | GLU54 |
| F | GLU55 |
| F | HOH2107 |
| F | HOH2108 |
| F | HOH2206 |
| F | HOH2207 |
| D | GLY53 |
| D | GLU54 |
| D | GLU55 |
| D | HOH2098 |
| D | HOH2099 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F1153 |
| Chain | Residue |
| F | ASN74 |
| F | LEU101 |
| F | SER102 |
| F | HOH2141 |
| F | HOH2153 |
| F | HOH2209 |
| F | HOH2210 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F1154 |
| Chain | Residue |
| F | LYS17 |
| F | THR27 |
| F | SER29 |
| F | HOH2211 |
| F | HOH2212 |
| K | MET151 |
| K | MET152 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 F1155 |
| Chain | Residue |
| F | LEU15 |
| F | GLY16 |
| F | LYS17 |
| F | ARG18 |
| F | HOH2032 |
| F | HOH2213 |
| F | HOH2214 |
| F | HOH2215 |
| F | HOH2216 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G1147 |
| Chain | Residue |
| G | ASN74 |
| G | HIS100 |
| G | LEU101 |
| G | SER102 |
| G | HOH2156 |
| site_id | CC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SO4 H1154 |
| Chain | Residue |
| G | GLY53 |
| G | GLU54 |
| G | GLU55 |
| G | HOH2065 |
| G | HOH2066 |
| H | GLY53 |
| H | GLU54 |
| H | GLU55 |
| H | HOH2084 |
| H | HOH2088 |
| H | HOH2192 |
| I | GLY53 |
| I | GLU54 |
| I | GLU55 |
| I | HOH2083 |
| I | HOH2085 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 H1155 |
| Chain | Residue |
| H | ASN74 |
| H | HIS100 |
| H | LEU101 |
| H | SER102 |
| H | HOH2139 |
| H | HOH2193 |
| H | HOH2194 |
| H | HOH2195 |
| H | HOH2196 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H1156 |
| Chain | Residue |
| H | LYS17 |
| H | THR27 |
| H | SER29 |
| H | HOH2197 |
| H | HOH2198 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H1157 |
| Chain | Residue |
| H | LEU15 |
| H | GLY16 |
| H | ARG18 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 I1147 |
| Chain | Residue |
| I | ASN74 |
| I | HIS100 |
| I | LEU101 |
| I | SER102 |
| I | HOH2019 |
| I | HOH2179 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 J1147 |
| Chain | Residue |
| J | ASN74 |
| J | HIS100 |
| J | LEU101 |
| J | SER102 |
| J | HOH2029 |
| J | HOH2115 |
| J | HOH2149 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 J1148 |
| Chain | Residue |
| J | LYS17 |
| J | THR27 |
| J | SER29 |
| J | HOH2150 |
| J | HOH2151 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 J1149 |
| Chain | Residue |
| J | LEU15 |
| J | GLY16 |
| J | LYS17 |
| J | ARG18 |
| J | ILE22 |
| J | TYR23 |
| J | GLY24 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 K1152 |
| Chain | Residue |
| K | ASN74 |
| K | HIS100 |
| K | LEU101 |
| K | SER102 |
| K | HOH2138 |
| K | HOH2194 |
| site_id | DC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 K1153 |
| Chain | Residue |
| K | LEU15 |
| K | GLY16 |
| K | LYS17 |
| K | ARG18 |
| K | HIS21 |
| K | ILE22 |
| K | TYR23 |
| K | GLY24 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 K1154 |
| Chain | Residue |
| F | GLN36 |
| F | TYR48 |
| K | MET1 |
| K | HOH2001 |
| K | HOH2195 |
| K | HOH2196 |
| K | HOH2197 |
| K | HOH2198 |
| K | HOH2199 |
| site_id | DC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SO4 L1147 |
| Chain | Residue |
| J | GLY53 |
| J | GLU54 |
| J | GLU55 |
| J | HOH2074 |
| K | GLY53 |
| K | GLU54 |
| K | GLU55 |
| K | HOH2090 |
| K | HOH2093 |
| L | GLY53 |
| L | GLU54 |
| L | GLU55 |
| L | HOH2084 |
| L | HOH2085 |
| L | HOH2088 |
| L | HOH2178 |
| site_id | DC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 L1148 |
| Chain | Residue |
| L | ASN74 |
| L | HIS100 |
| L | LEU101 |
| L | SER102 |
| L | HOH2130 |
| L | HOH2179 |
| L | HOH2180 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS B1149 |
| Chain | Residue |
| A | GLU54 |
| A | THR81 |
| A | SER82 |
| B | GLU54 |
| B | THR81 |
| C | GLU54 |
| C | THR81 |
| C | SER82 |
| site_id | DC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS E1150 |
| Chain | Residue |
| D | GLU54 |
| D | THR81 |
| D | SER82 |
| E | GLU54 |
| E | THR81 |
| F | GLU54 |
| F | THR81 |
| F | SER82 |
| site_id | DC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS H1158 |
| Chain | Residue |
| G | GLU54 |
| G | THR81 |
| G | SER82 |
| H | GLU54 |
| H | THR81 |
| I | GLU54 |
| I | THR81 |
| I | SER82 |
| site_id | DC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS K1155 |
| Chain | Residue |
| J | GLU54 |
| J | THR81 |
| J | SER82 |
| K | GLU54 |
| K | THR81 |
| L | GLU54 |
| L | THR81 |
| L | SER82 |
Functional Information from PROSITE/UniProt
| site_id | PS01029 |
| Number of Residues | 18 |
| Details | DEHYDROQUINASE_II Dehydroquinase class II signature. LNGPNLnmLGkREphiYG |
| Chain | Residue | Details |
| A | LEU7-GLY24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| A | GLU98 | |
| A | ARG107 | |
| A | HIS100 | |
| A | ARG18 | |
| A | ASN11 | |
| A | TYR23 |
| site_id | CSA10 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| J | GLU98 | |
| J | ARG107 | |
| J | HIS100 | |
| J | ARG18 | |
| J | ASN11 | |
| J | TYR23 |
| site_id | CSA11 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| K | GLU98 | |
| K | ARG107 | |
| K | HIS100 | |
| K | ARG18 | |
| K | ASN11 | |
| K | TYR23 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| L | GLU98 | |
| L | ARG107 | |
| L | HIS100 | |
| L | ASN11 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| B | GLU98 | |
| B | ARG107 | |
| B | HIS100 | |
| B | ASN11 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| C | GLU98 | |
| C | ARG107 | |
| C | HIS100 | |
| C | ARG18 | |
| C | ASN11 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| D | GLU98 | |
| D | ARG107 | |
| D | HIS100 | |
| D | ARG18 | |
| D | ASN11 | |
| D | TYR23 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| E | GLU98 | |
| E | ARG107 | |
| E | HIS100 | |
| E | ARG18 | |
| E | ASN11 | |
| E | TYR23 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| F | GLU98 | |
| F | ARG107 | |
| F | HIS100 | |
| F | ARG18 | |
| F | ASN11 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| G | GLU98 | |
| G | ARG107 | |
| G | HIS100 | |
| G | ARG18 | |
| G | ASN11 |
| site_id | CSA8 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| H | GLU98 | |
| H | ARG107 | |
| H | HIS100 | |
| H | ARG18 | |
| H | ASN11 |
| site_id | CSA9 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 14993670, 10360352 |
| Chain | Residue | Details |
| I | GLU98 | |
| I | ARG107 | |
| I | HIS100 | |
| I | ARG18 | |
| I | ASN11 |
