Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1UP7

Structure of the 6-phospho-beta glucosidase from Thermotoga maritima at 2.4 Angstrom resolution in the tetragonal form with NAD and glucose-6-phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0008706	molecular_function	6-phospho-beta-glucosidase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0046872	molecular_function	metal ion binding
A	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
B	0003824	molecular_function	catalytic activity
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0005975	biological_process	carbohydrate metabolic process
B	0008706	molecular_function	6-phospho-beta-glucosidase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0046872	molecular_function	metal ion binding
B	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
C	0003824	molecular_function	catalytic activity
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0005975	biological_process	carbohydrate metabolic process
C	0008706	molecular_function	6-phospho-beta-glucosidase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0046872	molecular_function	metal ion binding
C	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
D	0003824	molecular_function	catalytic activity
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0005975	biological_process	carbohydrate metabolic process
D	0008706	molecular_function	6-phospho-beta-glucosidase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0046872	molecular_function	metal ion binding
D	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
E	0003824	molecular_function	catalytic activity
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0005975	biological_process	carbohydrate metabolic process
E	0008706	molecular_function	6-phospho-beta-glucosidase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0046872	molecular_function	metal ion binding
E	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
F	0003824	molecular_function	catalytic activity
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0005975	biological_process	carbohydrate metabolic process
F	0008706	molecular_function	6-phospho-beta-glucosidase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0046872	molecular_function	metal ion binding
F	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
G	0003824	molecular_function	catalytic activity
G	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
G	0005975	biological_process	carbohydrate metabolic process
G	0008706	molecular_function	6-phospho-beta-glucosidase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
G	0046872	molecular_function	metal ion binding
G	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
H	0003824	molecular_function	catalytic activity
H	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
H	0005975	biological_process	carbohydrate metabolic process
H	0008706	molecular_function	6-phospho-beta-glucosidase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
H	0046872	molecular_function	metal ion binding
H	0103047	molecular_function	methyl beta-D-glucoside 6-phosphate glucohydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS01324
Number of Residues	32
Details	GLYCOSYL_HYDROL_F4 Glycosyl hydrolases family 4 signature. SnAtIVNftNPsghiTefvrnyleye.KfIGlC

Chain	Residue	Details
A	SER131-CYS162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR241
B	TYR241
C	TYR241
D	TYR241
E	TYR241
F	TYR241
G	TYR241
H	TYR241

site_id	SWS_FT_FI2
Number of Residues	56
Details	BINDING:

Chain	Residue	Details
A	MET1
B	ASN140
B	CYS162
B	ASN163
B	HIS192
B	ARG261
C	MET1
C	ARG87
C	ASN140
C	CYS162
C	ASN163
A	ARG87
C	HIS192
C	ARG261
D	MET1
D	ARG87
D	ASN140
D	CYS162
D	ASN163
D	HIS192
D	ARG261
E	MET1
A	ASN140
E	ARG87
E	ASN140
E	CYS162
E	ASN163
E	HIS192
E	ARG261
F	MET1
F	ARG87
F	ASN140
F	CYS162
A	CYS162
F	ASN163
F	HIS192
F	ARG261
G	MET1
G	ARG87
G	ASN140
G	CYS162
G	ASN163
G	HIS192
G	ARG261
A	ASN163
H	MET1
H	ARG87
H	ASN140
H	CYS162
H	ASN163
H	HIS192
H	ARG261
A	HIS192
A	ARG261
B	MET1
B	ARG87

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Increases basicity of active site Tyr => ECO:0000250

Chain	Residue	Details
A	GLU103
B	GLU103
C	GLU103
D	GLU103
E	GLU103
F	GLU103
G	GLU103
H	GLU103

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)