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1UOB

Deacetoxycephalosporin C synthase complexed with 2-oxoglutarate and penicillin G

Functional Information from GO Data
ChainGOidnamespacecontents
A0005506molecular_functioniron ion binding
A0009058biological_processbiosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016706molecular_function2-oxoglutarate-dependent dioxygenase activity
A0017000biological_processantibiotic biosynthetic process
A0031418molecular_functionL-ascorbic acid binding
A0050599molecular_functiondeacetoxycephalosporin-C synthase activity
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PNN A 1311
ChainResidue
AMET73
AVAL262
APHE264
AFE21310
AHOH2090
AHOH2156
ASER102
ALEU158
AMET180
AHIS183
AASP185
AILE192
AHIS243
ASER260

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FE2 A 1310
ChainResidue
AHIS183
AASP185
AHIS243
APNN1311
AAKG1312
AHOH2090

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE AKG A 1312
ChainResidue
AARG162
AMET180
AHIS183
AASP185
ALEU204
AHIS243
AARG258
ASER260
APHE264
AFE21310
AHOH2090

Functional Information from PROSITE/UniProt
site_idPS00186
Number of Residues14
DetailsIPNS_2 Isopenicillin N synthase signature 2. LVfCGAiaTlvTgG
ChainResidueDetails
ALEU223-GLY236

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1qje
ChainResidueDetails
AMET180

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1qje
ChainResidueDetails
ATYR163

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1qje
ChainResidueDetails
AARG74

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1qje
ChainResidueDetails
AARG160

site_idMCSA1
Number of Residues1
DetailsM-CSA 137
ChainResidueDetails
AARG74steric hindrance

226707

PDB entries from 2024-10-30

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