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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1UIO

ADENOSINE DEAMINASE (HIS 238 ALA MUTANT)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000255biological_processallantoin metabolic process
A0001666biological_processresponse to hypoxia
A0001701biological_processin utero embryonic development
A0001829biological_processtrophectodermal cell differentiation
A0001889biological_processliver development
A0001890biological_processplacenta development
A0002314biological_processgerminal center B cell differentiation
A0002467biological_processgerminal center formation
A0002636biological_processpositive regulation of germinal center formation
A0002686biological_processnegative regulation of leukocyte migration
A0002901biological_processmature B cell apoptotic process
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004000molecular_functionadenosine deaminase activity
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006196biological_processAMP catabolic process
A0006915biological_processapoptotic process
A0006939biological_processsmooth muscle contraction
A0007155biological_processcell adhesion
A0008270molecular_functionzinc ion binding
A0009117biological_processnucleotide metabolic process
A0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010460biological_processpositive regulation of heart rate
A0014074biological_processresponse to purine-containing compound
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019239molecular_functiondeaminase activity
A0019722biological_processcalcium-mediated signaling
A0030217biological_processT cell differentiation
A0030324biological_processlung development
A0030890biological_processpositive regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032261biological_processpurine nucleotide salvage
A0032263biological_processGMP salvage
A0032264biological_processIMP salvage
A0033077biological_processT cell differentiation in thymus
A0033081biological_processregulation of T cell differentiation in thymus
A0033089biological_processpositive regulation of T cell differentiation in thymus
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0042100biological_processB cell proliferation
A0042110biological_processT cell activation
A0043066biological_processnegative regulation of apoptotic process
A0043084biological_processpenile erection
A0043103biological_processhypoxanthine salvage
A0043605biological_processamide catabolic process
A0044209biological_processAMP salvage
A0045187biological_processregulation of circadian sleep/wake cycle, sleep
A0045580biological_processregulation of T cell differentiation
A0045582biological_processpositive regulation of T cell differentiation
A0045987biological_processpositive regulation of smooth muscle contraction
A0046059biological_processdAMP catabolic process
A0046061biological_processdATP catabolic process
A0046085biological_processadenosine metabolic process
A0046101biological_processhypoxanthine biosynthetic process
A0046103biological_processinosine biosynthetic process
A0046111biological_processxanthine biosynthetic process
A0046632biological_processalpha-beta T cell differentiation
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046872molecular_functionmetal ion binding
A0046936molecular_function2'-deoxyadenosine deaminase activity
A0048286biological_processlung alveolus development
A0048541biological_processPeyer's patch development
A0048566biological_processembryonic digestive tract development
A0050728biological_processnegative regulation of inflammatory response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050852biological_processT cell receptor signaling pathway
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0050870biological_processpositive regulation of T cell activation
A0050900biological_processleukocyte migration
A0060169biological_processnegative regulation of adenosine receptor signaling pathway
A0060205cellular_componentcytoplasmic vesicle lumen
A0060407biological_processnegative regulation of penile erection
A0070161cellular_componentanchoring junction
A0070242biological_processthymocyte apoptotic process
A0070244biological_processnegative regulation of thymocyte apoptotic process
A0070254biological_processmucus secretion
A0070256biological_processnegative regulation of mucus secretion
A0140928biological_processinhibition of non-skeletal tissue mineralization
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 400
ChainResidue
AHIS15
AHIS17
AHIS214
AASP295
AHPR353
site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HPR A 353
ChainResidue
APHE65
ATYR102
ASER103
AMET155
AALA183
AGLY184
AHIS214
AGLU217
AASP295
AASP296
AZN400
AHOH402
AHIS17
AASP19
APHE61
ALEU62
Functional Information from PROSITE/UniProt
site_idPS00485
Number of Residues7
DetailsA_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP
ChainResidueDetails
ASER291-PRO297
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"8634299","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ADA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ADA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Important for interaction with adenosine receptors and increasing their affinity for agonists","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsSite: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a4l
ChainResidueDetails
AALA238
ATYR240
AGLU217
AASP295
site_idMCSA1
Number of Residues6
DetailsM-CSA 376
ChainResidueDetails
AHIS15metal ligand
AHIS17metal ligand
AHIS214metal ligand
AGLU217proton shuttle (general acid/base)
AALA238proton shuttle (general acid/base)
AASP295metal ligand, steric role

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PDB entries from 2025-07-09

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