1UC3

Crystal Structure of hemoglobin I from river lamprey

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0015671	biological_process	oxygen transport
A	0016491	molecular_function	oxidoreductase activity
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0005344	molecular_function	oxygen carrier activity
B	0005506	molecular_function	iron ion binding
B	0015671	biological_process	oxygen transport
B	0016491	molecular_function	oxidoreductase activity
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0015671	biological_process	oxygen transport
C	0016491	molecular_function	oxidoreductase activity
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0005344	molecular_function	oxygen carrier activity
D	0005506	molecular_function	iron ion binding
D	0015671	biological_process	oxygen transport
D	0016491	molecular_function	oxidoreductase activity
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0015671	biological_process	oxygen transport
E	0016491	molecular_function	oxidoreductase activity
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
F	0005344	molecular_function	oxygen carrier activity
F	0005506	molecular_function	iron ion binding
F	0015671	biological_process	oxygen transport
F	0016491	molecular_function	oxidoreductase activity
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0015671	biological_process	oxygen transport
G	0016491	molecular_function	oxidoreductase activity
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
H	0005344	molecular_function	oxygen carrier activity
H	0005506	molecular_function	iron ion binding
H	0015671	biological_process	oxygen transport
H	0016491	molecular_function	oxidoreductase activity
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding
I	0005344	molecular_function	oxygen carrier activity
I	0005506	molecular_function	iron ion binding
I	0015671	biological_process	oxygen transport
I	0016491	molecular_function	oxidoreductase activity
I	0019825	molecular_function	oxygen binding
I	0020037	molecular_function	heme binding
I	0046872	molecular_function	metal ion binding
J	0005344	molecular_function	oxygen carrier activity
J	0005506	molecular_function	iron ion binding
J	0015671	biological_process	oxygen transport
J	0016491	molecular_function	oxidoreductase activity
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0046872	molecular_function	metal ion binding
K	0005344	molecular_function	oxygen carrier activity
K	0005506	molecular_function	iron ion binding
K	0015671	biological_process	oxygen transport
K	0016491	molecular_function	oxidoreductase activity
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0046872	molecular_function	metal ion binding
L	0005344	molecular_function	oxygen carrier activity
L	0005506	molecular_function	iron ion binding
L	0015671	biological_process	oxygen transport
L	0016491	molecular_function	oxidoreductase activity
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM A 150

Chain	Residue
A	PHE51
A	VAL111
A	TYR115
A	PHE116
A	LEU119
A	LEU145
A	HOH159
A	HOH161
A	HOH162
A	PHE52
A	LYS54
A	HIS73
A	ARG76
A	ALA80
A	LYS104
A	HIS105
A	PHE109

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM B 150

Chain	Residue
B	PHE51
B	PHE52
B	LYS54
B	HIS73
B	ARG76
B	ALA80
B	LEU101
B	LYS104
B	HIS105
B	PHE109
B	VAL111
B	TYR115
B	PHE116
B	LEU119
B	LEU145
B	HOH188

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM C 150

Chain	Residue
C	PHE51
C	PHE52
C	LYS54
C	HIS73
C	ARG76
C	ALA80
C	LYS104
C	HIS105
C	PHE109
C	VAL111
C	TYR115
C	PHE116
C	LEU119
C	LEU145
C	HOH166
C	HOH172
C	HOH211

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM D 150

Chain	Residue
D	PHE51
D	PHE52
D	LYS54
D	HIS73
D	ARG76
D	ALA80
D	LYS104
D	HIS105
D	PHE109
D	VAL111
D	TYR115
D	PHE116
D	LEU119
D	LEU145
D	HOH168
D	HOH169
D	HOH212

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM E 150

Chain	Residue
E	PHE51
E	PHE52
E	LYS54
E	HIS73
E	ARG76
E	ILE77
E	ALA80
E	LEU101
E	LYS104
E	HIS105
E	PHE109
E	TYR115
E	PHE116
E	LEU119
E	LEU145
E	HOH176
E	HOH192
E	HOH232

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM F 150

Chain	Residue
F	HOH188
F	HOH190
F	PHE51
F	PHE52
F	LYS54
F	HIS73
F	ARG76
F	LYS104
F	HIS105
F	PHE109
F	VAL111
F	TYR115
F	PHE116
F	LEU119
F	LEU145
F	HOH182

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM G 150

Chain	Residue
G	PHE51
G	PHE52
G	LYS54
G	HIS73
G	ARG76
G	ALA80
G	LEU101
G	LYS104
G	HIS105
G	PHE109
G	VAL111
G	TYR115
G	PHE116
G	LEU119
G	LEU145
G	HOH165
G	HOH171
G	HOH184

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM H 150

Chain	Residue
H	PHE51
H	PHE52
H	LYS54
H	HIS73
H	ARG76
H	ALA80
H	LEU101
H	LYS104
H	HIS105
H	PHE109
H	VAL111
H	TYR115
H	PHE116
H	LEU119
H	LEU145
H	HOH168

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM I 150

Chain	Residue
I	PHE51
I	PHE52
I	LYS54
I	HIS73
I	ARG76
I	LEU101
I	LYS104
I	HIS105
I	PHE109
I	TYR115
I	PHE116
I	LEU119
I	LEU145
I	HOH182
I	HOH220

---

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM J 150

Chain	Residue
J	PHE51
J	PHE52
J	LYS54
J	HIS73
J	ARG76
J	ALA80
J	LEU101
J	LYS104
J	HIS105
J	PHE109
J	VAL111
J	TYR115
J	PHE116
J	LEU119
J	LEU145
J	HOH163
J	HOH207
J	HOH213
J	HOH219

---

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM K 150

Chain	Residue
K	PHE51
K	PHE52
K	LYS54
K	HIS73
K	ARG76
K	LEU101
K	LYS104
K	HIS105
K	PHE109
K	VAL111
K	TYR115
K	PHE116
K	LEU119
K	HOH171
K	HOH208

---

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM L 150

Chain	Residue
L	PHE51
L	PHE52
L	LYS54
L	HIS73
L	ARG76
L	ALA80
L	LEU101
L	LYS104
L	HIS105
L	PHE109
L	VAL111
L	TYR115
L	PHE116
L	LEU119
L	LEU145
L	HOH168
L	HOH191

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: distal binding residue => ECO:0000255|PROSITE-ProRule:PRU00238

Chain	Residue	Details
A	ALA74
J	ALA74
K	ALA74
L	ALA74
B	ALA74
C	ALA74
D	ALA74
E	ALA74
F	ALA74
G	ALA74
H	ALA74
I	ALA74

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: proximal binding residue

Chain	Residue	Details
A	ALA106
J	ALA106
K	ALA106
L	ALA106
B	ALA106
C	ALA106
D	ALA106
E	ALA106
F	ALA106
G	ALA106
H	ALA106
I	ALA106

---