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1UA2

Crystal Structure of Human CDK7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000439cellular_componenttranscription factor TFIIH core complex
A0001111biological_processRNA polymerase II promoter clearance
A0001650cellular_componentfibrillar center
A0001673cellular_componentmale germ cell nucleus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005675cellular_componenttranscription factor TFIIH holo complex
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006281biological_processDNA repair
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0042795biological_processsnRNA transcription by RNA polymerase II
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0050821biological_processprotein stabilization
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0070516cellular_componentCAK-ERCC2 complex
A0070985cellular_componenttranscription factor TFIIK complex
A0106310molecular_functionprotein serine kinase activity
A0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
A0160239biological_processtranscription pausing by RNA polymerase II
A0160240biological_processRNA polymerase II transcription initiation surveillance
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
B0000166molecular_functionnucleotide binding
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000439cellular_componenttranscription factor TFIIH core complex
B0001111biological_processRNA polymerase II promoter clearance
B0001650cellular_componentfibrillar center
B0001673cellular_componentmale germ cell nucleus
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006281biological_processDNA repair
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006368biological_processtranscription elongation by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006974biological_processDNA damage response
B0008094molecular_functionATP-dependent activity, acting on DNA
B0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0042795biological_processsnRNA transcription by RNA polymerase II
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0050821biological_processprotein stabilization
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0070516cellular_componentCAK-ERCC2 complex
B0070985cellular_componenttranscription factor TFIIK complex
B0106310molecular_functionprotein serine kinase activity
B0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
B0160239biological_processtranscription pausing by RNA polymerase II
B0160240biological_processRNA polymerase II transcription initiation surveillance
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
C0000166molecular_functionnucleotide binding
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000439cellular_componenttranscription factor TFIIH core complex
C0001111biological_processRNA polymerase II promoter clearance
C0001650cellular_componentfibrillar center
C0001673cellular_componentmale germ cell nucleus
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005675cellular_componenttranscription factor TFIIH holo complex
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006281biological_processDNA repair
C0006366biological_processtranscription by RNA polymerase II
C0006367biological_processtranscription initiation at RNA polymerase II promoter
C0006368biological_processtranscription elongation by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006974biological_processDNA damage response
C0008094molecular_functionATP-dependent activity, acting on DNA
C0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0042795biological_processsnRNA transcription by RNA polymerase II
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048471cellular_componentperinuclear region of cytoplasm
C0050821biological_processprotein stabilization
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0070516cellular_componentCAK-ERCC2 complex
C0070985cellular_componenttranscription factor TFIIK complex
C0106310molecular_functionprotein serine kinase activity
C0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
C0160239biological_processtranscription pausing by RNA polymerase II
C0160240biological_processRNA polymerase II transcription initiation surveillance
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000166molecular_functionnucleotide binding
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0000439cellular_componenttranscription factor TFIIH core complex
D0001111biological_processRNA polymerase II promoter clearance
D0001650cellular_componentfibrillar center
D0001673cellular_componentmale germ cell nucleus
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005675cellular_componenttranscription factor TFIIH holo complex
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006281biological_processDNA repair
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0006368biological_processtranscription elongation by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006974biological_processDNA damage response
D0008094molecular_functionATP-dependent activity, acting on DNA
D0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
D0042795biological_processsnRNA transcription by RNA polymerase II
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048471cellular_componentperinuclear region of cytoplasm
D0050821biological_processprotein stabilization
D0051301biological_processcell division
D0051726biological_processregulation of cell cycle
D0070516cellular_componentCAK-ERCC2 complex
D0070985cellular_componenttranscription factor TFIIK complex
D0106310molecular_functionprotein serine kinase activity
D0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
D0160239biological_processtranscription pausing by RNA polymerase II
D0160240biological_processRNA polymerase II transcription initiation surveillance
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ATP A 381
ChainResidue
ALEU18
AASP92
APHE93
AMET94
ALYS139
AASN142
ASER161
AGLU20
AGLY21
AGLN22
APHE23
AALA24
AVAL26
AALA39
ALYS41

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ATP B 382
ChainResidue
BLEU18
BGLU20
BGLY21
BGLN22
BPHE23
BALA24
BVAL26
BALA39
BLYS41
BPHE91
BASP92
BPHE93
BMET94
BASN142
BSER161

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ATP C 383
ChainResidue
CGLU20
CGLY21
CGLN22
CPHE23
CALA24
CVAL26
CLYS41
CILE75
CASP92
CMET94
CASN142
CSER161

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ATP D 384
ChainResidue
DLEU18
DGLU20
DGLY21
DGLN22
DPHE23
DVAL26
DALA39
DLYS41
DILE75
DASP92
DPHE93
DMET94
DASN141
DASN142

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK
ChainResidueDetails
ALEU18-LYS42

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL
ChainResidueDetails
AILE133-LEU145

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:15530371
ChainResidueDetails
AASP137
BASP137
CASP137
DASP137

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15530371
ChainResidueDetails
ALEU18
ALYS41
BLEU18
BLYS41
CLEU18
CLYS41
DLEU18
DLYS41

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER7
BSER7
CSER7
DSER7

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CDK1 and CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER164
BSER164
CSER164
DSER164

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATPO170
BTPO170
CTPO170
DTPO170

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER321
BSER321
CSER321
DSER321

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASN141
AASP137

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BTHR175
BLYS139
BASP137

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CTHR175
CLYS139
CASP137

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DTHR175
DLYS139
DASP137

site_idCSA13
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASN142
ALYS139
AASP137

site_idCSA14
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASN142
BLYS139
BASP137

site_idCSA15
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASN142
CLYS139
CASP137

site_idCSA16
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASN142
DLYS139
DASP137

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASN141
BASP137

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASN141
CASP137

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASN141
DASP137

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ALYS139
AASP137

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS139
BASP137

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CLYS139
CASP137

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DLYS139
DASP137

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ATHR175
ALYS139
AASP137

237735

PDB entries from 2025-06-18

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