1U9O

Crystal structure of the transcriptional regulator EthR in a ligand bound conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CNS A 217

Chain	Residue
A	PHE110
A	PHE114
A	THR121
A	TYR148
A	ASN176
A	ASN179
A	PHE184
A	TRP207

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CNS B 217

Chain	Residue
B	PHE110
B	THR121
B	TYR148
B	THR149
B	ASN176
B	ASN179
B	GLU180
B	MET102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	SER46-PHE65
B	SER46-PHE65

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Inhibitor-binding

Chain	Residue	Details
A	ASN176
A	ASN179
B	ASN176
B	ASN179

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